Th17-related genes and celiac disease susceptibility

Medrano, Luz María; García Magariños, Manuel; Dema, Barbara; Espino, Laura; Maluenda, Carlos; Polanco, Isabel; Figueredo, María Ángeles; Fernández Arquero, Miguel; Núñez, Concepción

doi:10.1371/journal.pone.0031244

dc.creator	Medrano, Luz María	es_ES
dc.creator	García Magariños, Manuel	es_ES
dc.creator	Dema, Barbara	es_ES
dc.creator	Espino, Laura	es_ES
dc.creator	Maluenda, Carlos	es_ES
dc.creator	Polanco, Isabel	es_ES
dc.creator	Figueredo, María Ángeles	es_ES
dc.creator	Fernández Arquero, Miguel	es_ES
dc.creator	Núñez, Concepción	es_ES
dc.date.accessioned	2014-06-05T07:57:16Z
dc.date.available	2014-06-05T07:57:16Z
dc.date.issued	2012
dc.identifier.issn	1932-6203 (electronic)
dc.identifier.other	535
dc.identifier.uri	https://hdl.handle.net/2454/10743
dc.description.abstract	Th17 cells are known to be involved in several autoimmune or inflammatory diseases. In celiac disease (CD), recent studies suggest an implication of those cells in disease pathogenesis. We aimed at studying the role of genes relevant for the Th17 immune response in CD susceptibility. A total of 101 single nucleotide polymorphisms (SNPs), mainly selected to cover most of the variability present in 16 Th17-related genes (IL23R, RORC, IL6R, IL17A, IL17F, CCR6, IL6, JAK2, TNFSF15, IL23A, IL22, STAT3, TBX21, SOCS3, IL12RB1 and IL17RA), were genotyped in 735 CD patients and 549 ethnically matched healthy controls. Case-control comparisons for each SNP and for the haplotypes resulting from the SNPs studied in each gene were performed using chi-square tests. Gene-gene interactions were also evaluated following different methodological approaches. No significant results emerged after performing the appropriate statistical corrections. Our results seem to discard a relevant role of Th17 cells on CD risk.	en
dc.description.sponsorship	This work was supported by a grant from ‘‘Fondo de Investigaciones Sanitarias’’ (CP08/00213).	en
dc.format.mimetype	application/pdf	en
dc.language.iso	eng	en
dc.publisher	Public Library of Science	en
dc.relation.ispartof	Plos One, 2012, 7(2): e31244	en
dc.rights	© 2012 Medrano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.	en
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/
dc.subject	Genome wide association	en
dc.subject	Multiple sclerosis	en
dc.subject	Crohns disease	en
dc.subject	Risk	en
dc.subject	Variants	en
dc.subject	Th17 cells	en
dc.subject	IL23R	en
dc.subject	Gliadin	en
dc.subject	Interleukin 23	en
dc.subject	Autoimmunity	en
dc.subject	Inflammation	en
dc.title	Th17-related genes and celiac disease susceptibility	en
dc.type	Artículo / Artikulua	es
dc.type	info:eu-repo/semantics/article	en
dc.contributor.department	Estadística e Investigación Operativa	es_ES
dc.contributor.department	Estatistika eta Ikerketa Operatiboa	eu
dc.rights.accessRights	Acceso abierto / Sarbide irekia	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	en
dc.identifier.doi	10.1371/journal.pone.0031244
dc.relation.publisherversion	https://dx.doi.org/10.1371/journal.pone.0031244
dc.type.version	Versión publicada / Argitaratu den bertsioa	es
dc.type.version	info:eu-repo/semantics/publishedVersion	en

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© 2012 Medrano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

La licencia del ítem se describe como © 2012 Medrano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.