Morphological and biochemical characterization of a cell death process induced by E3, a new synthetic diarylsulfonilurea analogue
Fecha
2001Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Otros / Bestelakoak
Versión
Versión publicada / Argitaratu den bertsioa
Impacto
|
10.1100/tsw.2001.179
Resumen
With a view to finding new compounds with improved antitumoral
activity and reduced secondary effects, our group, using theoretical structure-activity studies,
has designed several analogues and derivatives of diarylsulfonilureas. These compounds
have been synthesized and tested “in vitro” on a panel of human tumor cell lines and showed
an antitumoral activity. In the present work, we have ch ...
[++]
With a view to finding new compounds with improved antitumoral
activity and reduced secondary effects, our group, using theoretical structure-activity studies,
has designed several analogues and derivatives of diarylsulfonilureas. These compounds
have been synthesized and tested “in vitro” on a panel of human tumor cell lines and showed
an antitumoral activity. In the present work, we have characterized the mechanisms
involved in the cell death process induced by one of these products called E3 in a CCRF-CEM
cell line. [--]
Materias
Cell death processes,
E3,
CCRF-CEM
Editor
Hindawi
Publicado en
The Scientific World Journal, Volume 1
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Universidad Pública de Navarra. Departamento de Química Aplicada /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila /
Nafarroako Unibertsitate Publikoa. Kimika Aplikatua Saila