Tesis doctorales DABA - ABES Doktoretza tesiak

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Papel de las tiorredoxinas plastidiales en la regulación del metabolismo del cloroplasto
(2019) Ancín Rípodas, María; Farrán Blanch, Inmaculada; Agronomía, Biotecnología y Alimentación; Agronomia, Bioteknologia eta Elikadura
Carbon (C) and nitrogen (N) are two essential nutrients required for plant growth and development. The cellular metabolism of both elements is tightly coordinated and subjected to a complex regulation. In this regard, the redox status operates as a major integrator of cellular metabolism, involving post-translational modifications of target enzymes by thiol-disulfide exchanges exerted by thioredoxins (Trxs). In plant chloroplasts two Trx systems function in parallel: (i) the ferredoxin (Fd)-Trx system that depends on photosynthetically reduced Fd to supply electrons to the Fd-Trx reductase, which in turn reduces Trxs; (ii) the NADPH dependent Trx reductase type C (NTRC) that contains both a Trx-reductase and a Trx domain in a single polypeptide. NTRC is reduced by NADPH, which in addition to the light reactions, is also produced in the oxidative pentose phosphate pathway in darkness. This PhD thesis has been focused on the regulatory role of plastid Trx f, m and NTRC in chloroplast metabolism.