Del Villar, Ignacio

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https://academica-e.unavarra.es/handle/2454/48889

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Del Villar

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Ignacio

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Ingeniería Eléctrica, Electrónica y de Comunicación

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ISC. Institute of Smart Cities

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0000-0002-8130-4035

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88663

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6918

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Author: Botero-Cadavid, Juan F. × Subject: Label-free immunosensors ×

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Now showing 1 - 2 of 2
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    PublicationOpen Access
    Optical fiber immunosensors optimized with cladding etching and ITO nanodeposition
    (IEEE, 2018) Cardona-Maya, Yamile; Del Villar, Ignacio; Socorro Leránoz, Abián Bentor; Corres Sanz, Jesús María; Botero-Cadavid, Juan F.; Institute of Smart Cities - ISC; Gobierno de Navarra / Nafarroako Gobernua
    Etched optical fiber immunosensors, with and without ITO nanodeposition, have been developed. The performance of these immunosensors has been assessed implementing an immunoassay. The sensitivity of the mmnunosensor increased by a factor of 4 with the ITO nanocoating, whereas the limit of the detection in both types of devices was 0.2 mg/L of antigens in solution.
  • Thumbnail Image
    PublicationOpen Access
    Label-free wavelength and phase detection based SMS fiber immunosensors optimized with cladding etching
    (Elsevier, 2018) Cardona-Maya, Yamile; Socorro Leránoz, Abián Bentor; Del Villar, Ignacio; Cruz, José Luis; Corres Sanz, Jesús María; Botero-Cadavid, Juan F.; Ingeniería Eléctrica y Electrónica; Ingeniaritza Elektrikoa eta Elektronikoa; Gobierno de Navarra / Nafarroako Gobernua 2016/PI044; Gobierno de Navarra / Nafarroako Gobernua 2016/PC025; Gobierno de Navarra / Nafarroako Gobernua 2016/PC026
    The performance of E-SMS (Etched Singlemode-Multimode-Singlemode) optical fiber structures as immunosensors has been assessed by the implementation of antibody/antigen immunoassays. Through this procedure it has been proven that E-SMS structures are effective and suitable optical platforms for label-free biosensing. Using the phase shift and tracking the wavelength response it was found that the fabricated E-SMS devices exhibited limits of detection (LOD) down up to concentrations of 0.2mg/L of antigens in solution. This was achieved by coating the E-SMS with an antibody-based biolayer (goat IgG) that is able to determine the presence of anti-goat IgG antigen. Both a wavelength detection and a fast Fourier transform (FFT) analysis technique were used to perform this analysis. The FFT method showed similar results to those observed with the most traditional wavelength analysis, but with the advantage of a simpler detection system that makes unnecessary the use of sophisticated optical interrogators.