Person: Garayo Urabayen, Eneko
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Garayo Urabayen
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Eneko
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Física
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0000-0002-3144-7898
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811381
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Publication Open Access Preparation of selenium-based drug-modified polymeric ligand-functionalised Fe3O4 nanoparticles as multimodal drug carrier and magnetic hyperthermia inductor(MDPI, 2023) Galarreta Rodríguez, Itziar; Etxebeste-Mitxeltorena, Mikel; Moreno, Esther; Plano, Daniel; Sanmartín, Carmen; Megahed, Saad; Feliu, Neus; Parak, Wolfgang J.; Garayo Urabayen, Eneko; Gil de Muro, Izaskun; Lezama, Luis; Ruiz de Larramendi, Idoia; Insausti, Maite; Ciencias; Zientziak; Institute for Advanced Materials and Mathematics - INAMAT2In recent years, much effort has been invested into developing multifunctional drug delivery systems to overcome the drawbacks of conventional carriers. Magnetic nanoparticles are not generally used as carriers but can be functionalised with several different biomolecules and their size can be tailored to present a hyperthermia response, allowing for the design of multifunctional systems which can be active in therapies. In this work, we have designed a drug carrier nanosystem based on Fe3O4 nanoparticles with large heating power and 4-amino-2-pentylselenoquinazoline as an attached drug that exhibits oxidative properties and high selectivity against a variety of cancer malignant cells. For this propose, two samples composed of homogeneous Fe3O4 nanoparticles (NPs) with different sizes, shapes, and magnetic properties have been synthesised and characterised. The surface modification of the prepared Fe3O4 nanoparticles has been developed using copolymers composed of poly(ethylene-alt-maleic anhydride), dodecylamine, polyethylene glycol and the drug 4-amino-2-pentylselenoquinazoline. The obtained nanosystems were properly characterised. Their in vitro efficacy in colon cancer cells and as magnetic hyperthermia inductors was analysed, thereby leaving the door open for their potential application as multimodal agents.Publication Open Access Magnetically activated 3D printable polylactic acid/polycaprolactone/magnetite composites for magnetic induction heating generation(Springer, 2023) Galarreta Rodríguez, Itziar; López Ortega, Alberto; Garayo Urabayen, Eneko; Beato López, Juan Jesús; La Roca, Paulo Matías; Sánchez-Alarcos Gómez, Vicente; Recarte Callado, Vicente; Gómez Polo, Cristina; Pérez de Landazábal Berganzo, José Ignacio; Ciencias; Zientziak; Institute for Advanced Materials and Mathematics - INAMAT2; Universidad Pública de Navarra / Nafarroako Unibertsitate PublikoaAdditive manufacturing technology has attracted the attention of industrial and technological sectors due to the versatility of the design and the easy manufacture of structural and functional elements based on composite materials. The embedding of magnetic nanoparticles in the polymeric matrix enables the development of an easy manufacturing process of low-cost magnetically active novel polymeric composites. In this work, we report a series of magnetic composites prepared by solution casting method combining 5 to 60 wt.% of 140 ± 50 nm commercial Fe3O4 nanoparticles, with a semi-crystalline, biocompatible, and biodegradable polymeric blend made of polylactic acid (PLA) and polycaprolactone (PCL). The composites were extruded, obtaining 1.5 ± 0.2 mm diameter continuous and flexible filaments for fused deposition modelling 3D printing. The chemical, magnetic, and calorimetric properties of the obtained filaments were investigated by differential scanning calorimetry, thermogravimetric analysis, magnetometry, and scanning electron microscopy. Furthermore, taking advantage of the magnetic character of the filaments, their capability to generate heat under the application of low-frequency alternating magnetic fields (magnetic induction heating) was analyzed. The obtained results expose the versatility of these easy manufacturing and low-cost filaments, where selecting a desired composition, the heating capacity can be properly adjusted for those applications where magnetic induction plays a key role (i.e., magnetic hyperthermia, drug release, heterogeneous catalysis, water electrolysis, gas capture, or materials synthesis).Publication Open Access Magnetic binary encoding system based on 3D printing and GMI detection prototype(Elsevier, 2022) Beato López, Juan Jesús; Algueta-Miguel, Jose M.; Galarreta Rodríguez, Itziar; López Ortega, Alberto; Garayo Urabayen, Eneko; Gómez Polo, Cristina; Aresti Bartolomé, Maite; Soria Picón, Eneko; Pérez de Landazábal Berganzo, José Ignacio; Institute for Advanced Materials and Mathematics - INAMAT2; Institute of Smart Cities - ISC; Ciencias; Ingeniería Eléctrica, Electrónica y de Comunicación; Zientziak; Ingeniaritza Elektrikoa, Elektronikoa eta Telekomunikazio Ingeniaritza; Gobierno de Navarra / Nafarroako Gobernua; Universidad Pública de Navarra / Nafarroako Unibertsitate PublikoaIn this work, the feasibility of a magnetic binary encoding system using 3D printing technology is analyzed. The study has a double interest, that is, the possibility of printing a 3D piece that contains the codified information and the development of a system for its decoding. For this purpose, magnetic nanoparticles (magnetite Fe3O4) were embedded in a polymeric matrix of Polylactic Acid (PLA) and Poly-ε-caprolactone (PCL). Similar to a conventional barcode, a rectangular piece with an alternating pattern of strips with absence (only polymer) and a 5 wt% of embedded magnetic nanoparticles was 3D printed employing the Fused Deposition Modelling tech- nique (FDM). The information was decoded by means of a Giant Magnetoimpedance (GMI) sensor-based pro- totype, by scanning the surface of the piece and measuring the changes in the magnetic field. As sensor nucleus, an amorphous soft magnetic wire of nominal composition (Co0.94 Fe0.06)72.5 Si12.5 B15 was employed. The decoding prototype incorporates a homemade electronic sensor interface that permits, at the time, the GMI sensor excitation and the subsequent signal conditioning to optimize its response. The output signal enables the detection of the magnetite nanoparticles and the magnetic decoding of the encoded information (“1” and “0”, presence or absence of the magnetic nanoparticles, respectively).Publication Open Access Non-linear GMI decoding in 3D printed magnetic encoded systems(Elsevier, 2023) Beato López, Juan Jesús; Algueta-Miguel, Jose M.; Galarreta Rodríguez, Itziar; Garayo Urabayen, Eneko; López Ortega, Alberto; Gómez Polo, Cristina; Pérez de Landazábal Berganzo, José Ignacio; Ciencias; Ingeniería Eléctrica, Electrónica y de Comunicación; Institute for Advanced Materials and Mathematics - INAMAT2; Institute of Smart Cities - ISC; Zientziak; Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren; Universidad Pública de Navarra / Nafarroako Unibertsitate PublikoaThe nonlinear giant magnetoimpedance (GMI) effect was explored as a highly sensitive sensing technology in 3D-printed magnetic encoded systems. Magnetic nanoparticles with low (magnetite, Fe3O4) and high (Co ferrite, Co0.7Fe2.3O4) magnetic remanence were embedded (10 wt%) in a polymeric matrix of Polylactic Acid (PLA) and Poly-ε-caprolactone (PCL) and extruded in magnetic filaments to be 3D printed by the Fused Deposition Modelling technique (FDM). Two different geometries were constructed namely, individual magnetic strips and fixed barcoded pieces. The stray magnetic fields generated by the magnetic nanoparticles were detected through the non-linear (second harmonic) GMI voltage using a soft magnetic CoFeSiB wire as the nucleus sensor. The decoding response was analyzed as a function of the magnetization remanence of the nanoparticles, the distance between the individual magnetic strips, and the position (height) of the GMI decoding sensor. It has been shown that modification of the net magnetization direction of each individual fixed strip within the barcode geometry is possible through the application of local external magnetic fields. This possibility improves the versatility of the 3D binary encoding system by adding an additional state (0 without nanoparticles, 1 or −1 depending on the relative orientation of the net magnetization along the strips) during the codifying procedure.