Publication:
Diverse methods with stereoselective induction in the asymmetric Biginelli reaction

Date

2024-08-15

Authors

Díaz Fernández, Marcos
Calvo Losada, Saturnino
Quirante, José Joaquín
Sarabia, Francisco
Pino-González, María Soledad

Director

Publisher

MDPI Publishing
Acceso abierto / Sarbide irekia
Artículo / Artikulua
Versión publicada / Argitaratu den bertsioa

Project identifier

AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-098296-BI00
AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122613OB-I00/ES/recolecta

Abstract

The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric synthetic advances in the formation of dihydropyrimidinones (DHPMs), dihydropyrimidinethiones (DHPMTs), and related compounds. The relevant bibliography on general processes in the Biginelli reaction and some methods of separation of isomers have also been referenced.

Description

Keywords

Pyrimidines, Multicomponent reactions, Asymmetric, Enantioselective, N-heterocycles, Biginelli reaction

Department

Institute for Advanced Materials and Mathematics - INAMAT2

Faculty/School

Degree

Doctorate program

item.page.cita

Díaz-Fernández, M., Algarra, M., Calvo-Losada, S., Quirante, J. J., Sarabia, F., Pino-González, M. S. (2024) Diverse methods with stereoselective induction in the asymmetric Biginelli reaction. Molecules, 29(16), 1-20. https://doi.org/10.3390/molecules29163864

item.page.rights

© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.

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