Understanding blood oxygenation in a microfluidic meander double side membrane contactor
| dc.contributor.author | Malankowska, Magdalena | |
| dc.contributor.author | Julián, Ignacio | |
| dc.contributor.author | Pellejero, Ismael | |
| dc.contributor.author | Rho, Hoon Suk | |
| dc.contributor.author | Schlautmann, Stefan | |
| dc.contributor.author | Tiggelaar, Roald M. | |
| dc.contributor.author | Pina, María del Pilar | |
| dc.contributor.author | Gardeniers, Han | |
| dc.contributor.author | Mallada, Reyes | |
| dc.contributor.department | Institute for Advanced Materials and Mathematics - INAMAT2 | en |
| dc.date.accessioned | 2020-01-27T09:50:39Z | |
| dc.date.available | 2021-07-01T23:00:16Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Lung disease is one of the most important causes of high morbidity in preterm infants. In this work, we study a simple and easy to fabricate microfluidic device that demonstrates a great potential for blood oxygenation. A meander type architecture with double side vertical membrane arrangement has been selected as reference model to investigate the oxygenation process. The design criteria for the fabricated devices has been to maximize the oxygen saturation level while ensuring the physiological blood flow in order to avoid thrombus formation and channel blockage during operation. A mathematical model for the oxygen transfer has been developed and validated by the experimental study. The obtained results demonstrate that blood was successfully oxygenated up to approximately 98% of O-2 saturation and that the oxygen transfer rate at 1 mL/min blood flow rate was approximately 92 mL/minm(2). Finally, a sensitivity analysis of the key parameters, i.e. size of the channel, oxygen concentration in the gas phase and oxygen permeation properties of the membrane, is carried out to discuss the performance limits and to settle the guidelines for future developments. | en |
| dc.description.sponsorship | The authors would like to acknowledge the financial support from the Government of Aragón and the Education, Audiovisual and Culture Executive Agency (EU-EACEA) within the EUDIME - 'Erasmus Mundus Doctorate in Membrane Engineering' program (FPA 2011-0014, SGA 2012-1719, http://eudime.unical.it). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011 financed by the Instituto de Salud Carlos III with the assistance of the European Regional Development Fund. Authors acknowledge the LMA-INA for offering access to their instruments and expertise. | en |
| dc.embargo.lift | 2021-07-01 | |
| dc.embargo.terms | 2021-07-01 | |
| dc.format.extent | 32 p. | |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | 10.1016/j.snb.2019.02.110 | |
| dc.identifier.issn | 0925-4005 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/36166 | |
| dc.language.iso | eng | en |
| dc.publisher | Elsevier | en |
| dc.relation.ispartof | Sensors and Actuators B: Chemical, 288 (2019), 414-424 | en |
| dc.relation.publisherversion | https://doi.org/10.1016/j.snb.2019.02.110 | |
| dc.rights | © 2019 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Blood oxygenation | en |
| dc.subject | Microfluidic membrane contactor | en |
| dc.title | Understanding blood oxygenation in a microfluidic meander double side membrane contactor | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | b4cb3430-7b46-428d-8714-7d9af415aebf | |
| relation.isAuthorOfPublication.latestForDiscovery | b4cb3430-7b46-428d-8714-7d9af415aebf |