Anti-inflammatory and chondroprotective effects induced by phenolic compounds from onion waste extracts in ATDC-5 chondrogenic cell line
| dc.contributor.author | Paesa, Mónica | |
| dc.contributor.author | Ancín Azpilicueta, Carmen | |
| dc.contributor.author | Velderrain-Rodríguez, Gustavo | |
| dc.contributor.author | Martín-Belloso, Olga | |
| dc.contributor.author | Gualillo, Oreste | |
| dc.contributor.author | Osada, Jesús | |
| dc.contributor.author | Rodríguez Yoldi, María Jesús | |
| dc.contributor.author | Mendoza, Gracia | |
| dc.contributor.department | Ciencias | es_ES |
| dc.contributor.department | Zientziak | eu |
| dc.contributor.department | Institute for Advanced Materials and Mathematics - INAMAT2 | en |
| dc.date.accessioned | 2023-04-05T10:20:42Z | |
| dc.date.available | 2023-04-05T10:20:42Z | |
| dc.date.issued | 2022 | |
| dc.date.updated | 2023-04-05T10:07:06Z | |
| dc.description.abstract | Osteoarthritis is a prevalent degenerative condition that is closely related to the destruction and inflammation of cartilage. The high prevalence of this pathology exhorts researchers to search for novel therapeutic approaches. Vegetable–fruit wastes have emerged as a promising origin of anti-inflammatory and antioxidant compounds that, in some cases, may also exert chondroprotective effects. This study aims to decipher the potential of onion waste products in the inhibition of molecular events involved in osteoarthritis. Onion extracts showed a high content of phenolic compounds and antioxidant properties. Cytocompatibility was demonstrated in the chondrogenic cell line ATDC-5, exerting viability percentages higher than 90% and a slight increase in the S phase cycle cell. The induction of inflammation mediated by the lipopolysaccharide and onion extracts’ treatment substantially inhibited molecular markers related to inflammation and cartilage degradation, highlighting the promising application of onion extracts in biomedical approaches. The in silico analyses suggested that the results could be attributed to protocatechuic, ellagic, and vanillic acids’ greater cell membrane permeability. Our work provides distinctive information about the possible application of waste onion extracts as functional components with anti-inflammatory and chondroprotective characteristics in osteoarthritis. | en |
| dc.description.sponsorship | This work was supported by the Grants: Proyectos en Salud AES 2021 (PI21/00911; ISCIII), CIBER-BBN, CIBEROBN, Ministerio de Ciencia e Innovación-Fondo Europeo de Desarrollo Regional (PID2019-104915RB-I00), Fondo Social Europeo-Gobierno de Aragón (B16_20R) and SUDOE (Redvalue, SOE1/PI/E0123). This research was also funded by European Union’s H2020 research and innovation program under Marie Sklodowska-Curie grant agreement number 801586. G.M. gratefully acknowledges the support from the Miguel Servet Program (MS19/00092; ISCIII). M.P. acknowledges the support from the Gobierno de Aragón fellowship (CUS/581/2020). O.G. is Staff Personnel (I3SNS Stable Researcher) of Xunta de Galicia (Servizo Galego de Saude (SERGAS)) through a research-staff contract (ISCIII)/SERGAS). | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Paesa, M., Ancín-Azpilicueta, C., Velderrain-Rodríguez, G., Martin-Belloso, O., Gualillo, O., Osada, J., Rodríguez-Yoldi, M. J., & Mendoza, G. (2022). Anti-Inflammatory and Chondroprotective Effects Induced by Phenolic Compounds from Onion Waste Extracts in ATDC-5 Chondrogenic Cell Line. Antioxidants, 11(12), 2381. https://doi.org/10.3390/antiox11122381 | en |
| dc.identifier.doi | 10.3390/antiox11122381 | |
| dc.identifier.issn | 2076-3921 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/45073 | |
| dc.language.iso | eng | en |
| dc.publisher | MDPI | en |
| dc.relation.ispartof | Antioxidants, 2022, 11(12), 1-14 | en |
| dc.relation.projectID | info:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/801586/ | |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104915RB-I00/ES/ | |
| dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F00911/ES/ | |
| dc.relation.publisherversion | https://doi.org/10.3390/antiox11122381 | |
| dc.rights | © 2022 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Allium cepa L. waste extracts | en |
| dc.subject | Chondroprotective | en |
| dc.subject | Circular economy | en |
| dc.subject | Inflammation | en |
| dc.subject | NF-κB | en |
| dc.subject | Osteoarthritis | en |
| dc.subject | ROS | en |
| dc.title | Anti-inflammatory and chondroprotective effects induced by phenolic compounds from onion waste extracts in ATDC-5 chondrogenic cell line | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | 0c68430e-1a8d-4e76-a5db-679f3359e8c4 | |
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