Resistance training and clinical status in patients with postdischarge symptoms after COVID-19: protocol for a randomized controlled crossover trial 'The EXER-COVID Crossover Study'.

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dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.authorOteiza Olaso, Julio
dc.contributor.authorCasas Fernández de Tejerina, Juan Manuel
dc.contributor.authorGarcía Alonso, Nora
dc.contributor.authorLegarra Gorgoñón, Gaizka
dc.contributor.authorOscoz Ochandorena, Sergio
dc.contributor.authorArasanz Esteban, Hugo
dc.contributor.authorGarcía Alonso, Yesenia
dc.contributor.authorCorrea Rodríguez, María
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2022-09-28T15:19:34Z
dc.date.available2022-09-28T15:19:34Z
dc.date.issued2022
dc.date.updated2022-09-28T07:42:11Z
dc.description.abstractBackground: physical exercise induces a coordinated response of multiple organ systems, including the immune system. In fact, it has been proposed that physical exercise may modulate the immune system. However, the potential effect of an exercise program on COVID-19 survivors has not been investigated. Thus, the aim of this study is to evaluate the modifications in immunological parameters, physical condition, inflammatory profile, and perceived persistent symptoms after 6 weeks of supervised resistance training (RT), in addition to the standard care on the clinical status of patients with persistent COVID-19 symptoms. The objective of this protocol is to describe the scientific rationale in detail and to provide information about the study procedures. Methods/design: a total of 100 patients with postdischarge symptoms after COVID-19 will be randomly allocated into either a group receiving standard care (control group) or a group performing a multicomponent exercise program two times a week over a period of 6 weeks. The main hypothesis is that a 6-week multicomponent exercise program (EXER-COVID Crossover Study) will improve the immunological and inflammatory profile, physical condition, and persistent perceived symptoms (fatigue/tiredness, musculoskeletal pain, and shortness of breath) in patients with postdischarge symptoms after COVID-19. Discussion: our results will provide insights into the effects of a multicomponent exercise program on immunological parameters, physical condition, inflammatory profile, and persistent perceived symptoms in patients with postdischarge symptoms after COVID-19. Information obtained by this study will inform future guidelines on the exercise training rehabilitation of patients with postdischarge symptoms after COVID-19.en
dc.description.sponsorshipThe EXER-COVID Crossover Study was supported by «Proyectos de I+D+i» de los Programas Estatales de Generación de Conocimiento y Fortalecimiento Científico y Tecnológico del Sistema de I+D+i Orientada a los Retos de la Sociedad, en el marco del Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (PID2020-113098RB-I00).es
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dc.format.mimetypeapplication/zipen
dc.identifier.citationRamírez-Vélez, R.; Oteiza, J.; Casas Fernández de Tejerina, J. M.; García-Alonso, N.; Legarra-Gorgoñon, G.; Oscoz-Ochandorena, S.; Arasanz, H.; García-Alonso, Y.; Correa-Rodríguez, M.; Izquierdo, M.. (2022). Resistance training and clinical status in patients with postdischarge symptoms after COVID-19: protocol for a randomized controlled crossover trial "The EXER-COVID Crossover Study". Trials. 23.en
dc.identifier.doi10.1186/s13063-022-06608-y
dc.identifier.issn1745-6215
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/44099
dc.language.isoengen
dc.publisherBMC
dc.relation.ispartofTrials, (2022) 23:643es
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113098RB-I00/ES/
dc.relation.publisherversionhttps://doi.org/10.1186/s13063-022-06608-y
dc.rights© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International Licenseen
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19en
dc.subjectMulticomponent exerciseen
dc.subjectInflammationen
dc.subjectImmunologyen
dc.titleResistance training and clinical status in patients with postdischarge symptoms after COVID-19: protocol for a randomized controlled crossover trial 'The EXER-COVID Crossover Study'.en
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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