Publication: Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment
dc.contributor.author | Celay Leoz, Ion | |
dc.contributor.author | Blanco Luquin, Idoia | |
dc.contributor.author | Lázcoz Ripoll, Paula | |
dc.contributor.author | Rotinen Díaz, Mirja Sofia | |
dc.contributor.author | Castresana, Javier S. | |
dc.contributor.author | Encío Martínez, Ignacio | |
dc.contributor.department | Ciencias de la Salud | es_ES |
dc.contributor.department | Osasun Zientziak | eu |
dc.contributor.funder | Gobierno de Navarra / Nafarroako Gobernua | es |
dc.date.accessioned | 2018-09-06T12:20:21Z | |
dc.date.available | 2018-09-06T12:20:21Z | |
dc.date.issued | 2013 | |
dc.description.abstract | To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers induced apoptosis and reduced cell density as a result of cell differentiation and/or apoptosis. Flow cytometry revealed that 9-cis RA induced apoptosis more effectively than ATRA. The expression profile of apoptosis and survival pathways was cell line specific and depended on the isomer used. | en |
dc.description.sponsorship | This work was supported by grants from the Departmento de Salud, Gobierno de Navarra, Pamplona, and from the Fondo de Investigación Sanitaria (PI08/1849), Madrid, Spain. | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.doi | 10.1371/journal.pone.0062771 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/30552 | |
dc.language.iso | eng | en |
dc.publisher | Public Library of Science | en |
dc.relation.ispartof | Plos One, 8(5): e62771 | en |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0062771 | |
dc.rights | © 2013 Celay et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
dc.subject | Retinoic acid | en |
dc.subject | Neuroblastoma | en |
dc.subject | Apoptosis | en |
dc.title | Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment | en |
dc.type | info:eu-repo/semantics/article | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
dspace.entity.type | Publication | |
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