Publication:
Preparation of selenium-based drug-modified polymeric ligand-functionalised Fe3O4 nanoparticles as multimodal drug carrier and magnetic hyperthermia inductor

Simple item page
dc.contributor.authorGalarreta Rodríguez, Itziar
dc.contributor.authorEtxebeste-Mitxeltorena, Mikeles_ES
dc.contributor.authorMoreno, Estheres_ES
dc.contributor.authorPlano, Danieles_ES
dc.contributor.authorSanmartín, Carmenes_ES
dc.contributor.authorMegahed, Saades_ES
dc.contributor.authorFeliu, Neuses_ES
dc.contributor.authorParak, Wolfgang J.es_ES
dc.contributor.authorGarayo Urabayen, Eneko
dc.contributor.authorGil de Muro, Izaskunes_ES
dc.contributor.authorLezama, Luises_ES
dc.contributor.authorRuiz de Larramendi, Idoiaes_ES
dc.contributor.authorInsausti, Maitees_ES
dc.contributor.departmentCienciases_ES
dc.contributor.departmentZientziakeu
dc.contributor.departmentInstitute for Advanced Materials and Mathematics - INAMAT2en
dc.date.accessioned2023-11-07T16:57:38Z
dc.date.available2023-11-07T16:57:38Z
dc.date.issued2023
dc.date.updated2023-11-07T16:18:43Z
dc.description.abstractIn recent years, much effort has been invested into developing multifunctional drug delivery systems to overcome the drawbacks of conventional carriers. Magnetic nanoparticles are not generally used as carriers but can be functionalised with several different biomolecules and their size can be tailored to present a hyperthermia response, allowing for the design of multifunctional systems which can be active in therapies. In this work, we have designed a drug carrier nanosystem based on Fe3O4 nanoparticles with large heating power and 4-amino-2-pentylselenoquinazoline as an attached drug that exhibits oxidative properties and high selectivity against a variety of cancer malignant cells. For this propose, two samples composed of homogeneous Fe3O4 nanoparticles (NPs) with different sizes, shapes, and magnetic properties have been synthesised and characterised. The surface modification of the prepared Fe3O4 nanoparticles has been developed using copolymers composed of poly(ethylene-alt-maleic anhydride), dodecylamine, polyethylene glycol and the drug 4-amino-2-pentylselenoquinazoline. The obtained nanosystems were properly characterised. Their in vitro efficacy in colon cancer cells and as magnetic hyperthermia inductors was analysed, thereby leaving the door open for their potential application as multimodal agents.en
dc.description.sponsorshipThis work was supported by institutional funding from the Ministry of Economy and Competitiveness and Basque Government under projects PID2019-106845RB-100 (AEI/FEDER, UE) and GIC-IT-1546-22. WJP was supported by the Cluster of Excellence Advanced Imaging of Matter of the Deursche Forschungsgemeinschaft (DFG)-EXC 2056—project ID 390715994. SM was financed by a PhD fellowship from the German Academic Exchange Service (DAAD). NF was supported by Fraunhofer Attract.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGalarreta-Rodriguez, I., Etxebeste-Mitxeltorena, M., Moreno, E., Plano, D., Sanmartín, C., Megahed, S., Feliu, N., ParakW. J., Garaio, E., Gil de Muro, I., Lezama, L., Ruiz de Larramendi, I., Insausti, M. (2023) Preparation of selenium-based drug-modified polymeric ligand-functionalised Fe3O4 nanoparticles as multimodal drug carrier and magnetic hyperthermia inductor. Pharmaceuticals, 16(7). https://doi.org/10.3390/ph16070949.en
dc.identifier.doi10.3390/ph16070949
dc.identifier.issn1424-8247
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/46726
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofPharmaceuticals 2023, 16(7), 949en
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106845RB-I00/ES/en
dc.relation.publisherversionhttps://doi.org/10.3390/ph16070949
dc.rights© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDrug carriersen
dc.subjectMagnetic hyperthermia inductoren
dc.subjectMagnetic nanoparticlesen
dc.titlePreparation of selenium-based drug-modified polymeric ligand-functionalised Fe3O4 nanoparticles as multimodal drug carrier and magnetic hyperthermia inductoren
dc.typeArtículo / Artikuluaes
dc.typeinfo:eu-repo/semantics/articleen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
relation.isAuthorOfPublication21704783-63a6-4888-9cda-d012adcf839b
relation.isAuthorOfPublicationef0a109c-acf3-4a8f-bdf8-c9b4fcbf1172
relation.isAuthorOfPublication.latestForDiscovery21704783-63a6-4888-9cda-d012adcf839b

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Galarreta_PreparationSelenium.pdf
Size:
2.42 MB
Format:
Adobe Portable Document Format
Download
Thumbnail Image
Name:
Galarreta_PreparationSelenium_MatCompl.pdf
Size:
976.35 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.78 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista DCIE - ZIES Aldizkari artikuluak
Artículos de revista - Aldizkari artikuluak
Artículos de revista INAMAT2 - INAMAT2 aldizkari artikuluak