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Unravelling the phytotoxic effects of glyphosate on sensitive and resistant Amaranthus Palmeri populations by GC-MS and LC-MS metabolic profiling

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dc.contributor.authorZulet González, Ainhoa
dc.contributor.authorGorzolka, Karin
dc.contributor.authorDöll, Stefanie
dc.contributor.authorGil Monreal, Miriam
dc.contributor.authorRoyuela Hernando, Mercedes
dc.contributor.authorZabalza Aznárez, Ana
dc.contributor.departmentInstitute for Multidisciplinary Research in Applied Biology - IMABen
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoaes
dc.date.accessioned2023-07-27T15:19:43Z
dc.date.available2023-07-27T15:19:43Z
dc.date.issued2023
dc.date.updated2023-07-27T15:15:36Z
dc.description.abstractGlyphosate, the most successful herbicide in history, specifically inhibits the activity of the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS; EC 2.5.1.19), one of the key enzymes in the shikimate pathway. Amaranthus palmeri is a driver weed in agriculture today that has evolved glyphosate-resistance through increased EPSPS gene copy number and other mechanisms. Non-targeted GC–MS and LC–MS metabolomic profiling was conducted to examine the innate physiology and the glyphosate-induced perturbations in one sensitive and one resistant (by EPSPS amplification) population of A. palmeri. In the absence of glyphosate treatment, the metabolic profile of both populations was very similar. The comparison between the effects of sublethal and lethal doses on sensitive and resistant populations suggests that lethality of the herbicide is associated with an amino acid pool imbalance and accumulation of the metabolites of the shikimate pathway upstream from EPSPS. Ferulic acid and its derivatives were accumulated in treated plants of both populations, while quercetin and its derivative contents were only lower in the resistant plants treated with glyphosate.en
dc.description.sponsorshipThis work was funded by the Spanish Ministry of Economy and Competitiveness (AGL2016-77531-R) and Spanish Ministry of Science and Innovation (2020 117723-RB-100). A. Z-G received funding from fellowship through Universidad Pública de Navarra.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationZulet-Gonzalez, A., Gorzolka, K., Döll, S., Gil-Monreal, M., Royuela, M., Zabalza-Aznárez, A. (2023) Unravelling the phytotoxic effects of glyphosate on sensitive and resistant Amaranthus Palmeri populations by GC-MS and LC-MS metabolic profiling. Plants, 12(6), 1-17. https://doi.org/10.3390/plants12061345.en
dc.identifier.doi10.3390/plants12061345
dc.identifier.issn2223-7747
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/45846
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofPlants 2023, 12(6), 1345en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//AGL2016-77531-Ren
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//2020 117723-RB-100en
dc.relation.publisherversionhttps://doi.org/10.3390/plants12061345
dc.rights© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEPSPSen
dc.subjectFlavonoidsen
dc.subjectMode of actionen
dc.subjectNon-targeted metabolomicsen
dc.subjectPhenylpropanoidsen
dc.subjectPrimary metabolismen
dc.subjectSignalling moleculesen
dc.titleUnravelling the phytotoxic effects of glyphosate on sensitive and resistant Amaranthus Palmeri populations by GC-MS and LC-MS metabolic profilingen
dc.typeinfo:eu-repo/semantics/article
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
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relation.isAuthorOfPublicationb62dd25b-6298-44fe-8690-12267f5b3d70
relation.isAuthorOfPublication050bc121-21c9-467d-8bb6-611a789b1011
relation.isAuthorOfPublication0085d805-7945-48bf-994f-85bc2c88d92b
relation.isAuthorOfPublication.latestForDiscoverye9c604fa-a610-4c8b-81fd-f9352c2c8601

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