Heart rate from progressive volitional cycling test is associated with endothelial dysfunction outcomes in hypertensive chilean adults

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dc.contributor.authorÁlvarez, Cristian
dc.contributor.authorTuesta, Marcelo
dc.contributor.authorReyes, Álvaro
dc.contributor.authorGuede-Rojas, Francisco
dc.contributor.authorPeñailillo, Luis
dc.contributor.authorCigarroa, Igor
dc.contributor.authorVásquez-Gómez, Jaime
dc.contributor.authorCano Montoya, Johnattan
dc.contributor.authorDurán-Marín, Cristóbal
dc.contributor.authorRojas-Paz, Oscar
dc.contributor.authorMárquez, Héctor
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.authorDelgado Floody, Pedro
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2023-06-13T13:20:17Z
dc.date.available2023-06-13T13:20:17Z
dc.date.issued2023
dc.date.updated2023-06-13T13:10:07Z
dc.description.abstractBackground: A progressive volitional cycling test is useful in determining exercise prescription in populations with cardiovascular and metabolic diseases. However, little is known about the association between heart rate during this test and endothelial dysfunction (EDys) parameters in hypertensive (HTN) patients. Objective: To investigate the association between EDys markers (flow-mediated dilation [FMD], pulse wave velocity of the brachial artery [PWVba], and carotid-intima media thickness [cIMT]) and heart rate during a cycling test in HTN adults. A secondary aim was to characterize cardiovascular, anthropometric, and body composition outcomes in this population. Methods: This was a descriptive clinical study in which adults (men and women) were assigned to one of three groups: HTN, elevated blood pressure (Ele), or a normotensive control group (CG), and completed a progressive cycling test. The primary outcomes were FMD, PWVba, cIMT, and heart rate (HR) at 25–50 watts (HR25–50), 50–100 watts (HR50–100), and 75–150 watts (HR75–150) of the Astrand test. Secondary outcomes included body mass index (BMI), waist circumference, body fat percentage (BF%), skeletal muscle mass (SMM), resting metabolic rate (RMR), and estimated body age, as measured by a bio-impedance digital scale. Results: Analyses of the associations between FMD, PWV, and HR25–50, HR50–100, and HR75–150 watts revealed no significant association in the HTN, Ele, and CG groups. However, a significant association was found between cIMT and HR75–150 watts in the HTN group (R2 47.1, β −0.650, p = 0.038). There was also a significant trend (p = 0.047) towards increasing PWVba in the CG, Ele, and HTN groups. Conclusion: Heart rate during a progressive cycling test is associated with the EDys parameters cIMT in HTN patients, with particularly strong predictive capacity for vascular parameters in the second and third stages of the Astrand exercise test compared to normotensive control.en
dc.description.sponsorshipThis research was funded by Direccion General de Investigación, Vicerrectoria de Investigación y Doctorado, Concurso de Ciencias Biomédicas y Clínicas, Universidad Andres Bello 2022 Código N DI-01-CBC/22.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAlvarez, C., Tuesta, M., Reyes, Á., Guede-Rojas, F., Peñailillo, L., Cigarroa, I., Vásquez-Gómez, J., Cano-Montoya, J., Durán-Marín, C., Rojas-Paz, O., Márquez, H., Izquierdo, M., & Delgado-Floody, P. (2023). Heart rate from progressive volitional cycling test is associated with endothelial dysfunction outcomes in hypertensive chilean adults. International Journal of Environmental Research and Public Health, 20(5), 4236. https://doi.org/10.3390/ijerph20054236en
dc.identifier.doi10.3390/ijerph20054236
dc.identifier.issn1661-7827
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/45483
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofInternational Journal of Environmental Research and Public Health 2023, 20(5), 4236en
dc.relation.publisherversionhttps://doi.org/10.3390/ijerph20054236
dc.rights© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectFlow-mediated dilationen
dc.subjectPulse wave velocityen
dc.subjectCarotid-intima media thicknessen
dc.subjectEndothelial dysfunctionen
dc.subjectArterial hypertensionen
dc.subjectExercise testen
dc.subjectVasculatureen
dc.titleHeart rate from progressive volitional cycling test is associated with endothelial dysfunction outcomes in hypertensive chilean adultsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationef73585d-4750-4f56-9d4f-0d759232dbca
relation.isAuthorOfPublication.latestForDiscoveryef73585d-4750-4f56-9d4f-0d759232dbca

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