A combination of apple vinegar drink with Bacillus coagulans ameliorates high fat diet-induced body weight gain, insulin resistance and hepatic steatosis
| dc.contributor.author | Urtasun Alonso, Raquel | |
| dc.contributor.author | Araña Ciordia, Miriam | |
| dc.contributor.author | Pajares Villandiego, María Josefa | |
| dc.contributor.author | Oneca Agurruza, María | |
| dc.contributor.author | Torre Hernández, Paloma | |
| dc.contributor.author | Barajas Vélez, Miguel Ángel | |
| dc.contributor.author | Encío Martínez, Ignacio | |
| dc.contributor.department | Ciencias de la Salud | es_ES |
| dc.contributor.department | Osasun Zientziak | eu |
| dc.contributor.department | Ciencias | es_ES |
| dc.contributor.department | Zientziak | eu |
| dc.contributor.funder | Gobierno de Navarra / Nafarroako Gobernua | es |
| dc.date.accessioned | 2021-01-11T11:43:50Z | |
| dc.date.available | 2021-01-11T11:43:50Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Obesity is a worldwide epidemic characterized by excessive fat accumulation, associated with multiple comorbidities and complications. Emerging evidence points to gut microbiome as a driving force in the pathogenesis of obesity. Vinegar intake, a traditional remedy source of exogenous acetate, has been shown to improve glycemic control and to have anti-obesity effects. New functional foods may be developed by supplementing traditional food with probiotics. B. coagulans is a suitable choice because of its resistance to high temperatures. To analyze the possible synergic effect of Vinegar and B. coagulans against the metabolic alterations induced by a high fat diet (HFD), we fed twelve-week-old C57BL/6 mice with HFD for 5 weeks after 2 weeks of acclimation on a normal diet. Then, food intake, body weight, blood biochemical parameters, histology and liver inflammatory markers were analyzed. Although vinegar drink, either alone or supplemented with B. coagulans, reduced food intake, attenuated body weight gain and enhanced glucose tolerance, only the supplemented drink improved the lipid serum profile and prevented hepatic HFD-induced overexpression of CD36, IL-1β, IL-6, LXR and SREBP, thus reducing lipid deposition in the liver. The beneficial properties of the B. coagulans-supplemented vinegar appear to be mediated by a reduction in insulin and leptin circulating levels. | en |
| dc.description.sponsorship | This research was funded by grant from Department of Economic Development, Navarre Government [Modalidad: 'Transferencia del Conocimiento', References: 0011-1365-2018-000111 (UPNA) and 0011-1365-2018-000170 (ECOVINAL, S.L.U.)]. | en |
| dc.format.extent | 19 p. | |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | 10.3390/nu12092504 | |
| dc.identifier.issn | 2072-6643 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/38976 | |
| dc.language.iso | eng | en |
| dc.publisher | MDPI | en |
| dc.relation.ispartof | Nutrients, 2020, 12(9):2504 | en |
| dc.relation.publisherversion | https://doi.org/10.3390/nu12092504 | |
| dc.rights | © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Obesity | en |
| dc.subject | High fat diet | en |
| dc.subject | Insulin resistance | en |
| dc.subject | Hepatic steatosis | en |
| dc.subject | Vinegar | en |
| dc.subject | Bacillus coagulans | en |
| dc.title | A combination of apple vinegar drink with Bacillus coagulans ameliorates high fat diet-induced body weight gain, insulin resistance and hepatic steatosis | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
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