20-Year trajectories of six psychopathological dimensions in patients with first-episode psychosis: could they be predicted?

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dc.contributor.authorCuesta, Manuel J.
dc.contributor.authorGil Berrozpe, Gustavo José
dc.contributor.authorSánchez Torres, Ana María
dc.contributor.authorMoreno-Izco, Lucía
dc.contributor.authorGarcía de Jalón, Elena
dc.contributor.authorPeralta Martín, Víctor
dc.contributor.authorSEGPEPs Group
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2024-04-25T08:38:27Z
dc.date.issued2024
dc.date.updated2024-04-25T08:10:26Z
dc.description.abstractPatients with first-episode psychoses (FEP) exhibit heterogeneity in clinical manifestations and outcomes. This study investigated the long-term trajectories of six key psychopathological dimensions (reality-distortion, negative, disorganization, catatonia, mania and depression) in patients diagnosed with FEP. A total of 243 patients were followed up for 20 years and the trajectories of the dimensions were analysed using growth mixture modelling. These dimensions showed varied course patterns, ranging from two to five trajectories. Additionally, the study examined the predictive value of different factors in differentiating between the long-term trajectories. The exposome risk score showed that familial load, distal and intermediate risk factors, acute psychosocial stressors and acute onset were significant predictors for differentiating between long-term psychopathological trajectories. In contrast, polygenic risk score, duration of untreated psychosis and duration of untreated illness demonstrated little or no predictive value. The findings highlight the importance of conducting a multidimensional assessment not only at FEP but also during follow-up to customize the effectiveness of interventions. Furthermore, the results emphasize the relevance of assessing premorbid predictors from the onset of illness. This may enable the identification of FEP patients at high-risk of poor long-term outcomes who would benefit from targeted prevention programs on specific psychopathological dimensions.en
dc.description.sponsorshipThis work was supported by the Government of Navarra (grants 17/31 and 18/41 ) and by the Carlos III Health Institute (FEDER Funds) from the Spanish Ministry of Economy and Competitivity (16/2148, 19/1698 and RD21/0009/0025).en
dc.embargo.inicio2024-04-25
dc.embargo.lift2025-01-01
dc.embargo.terms2025-01-01
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.identifier.citationCuesta, M. J., Gil-Berrozpe, G. J., Sánchez-Torres, A. M., Moreno-Izco, L., García de Jalón, E., Peralta, V. (2024) 20-Year trajectories of six psychopathological dimensions in patients with first-episode psychosis: Could they be predicted?. Psychiatry Research, 331. https://doi.org/10.1016/j.psychres.2023.115614.
dc.identifier.doi10.1016/j.psychres.2023.115614
dc.identifier.issn0165-1781
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/48033
dc.language.isoengen
dc.publisherElsevieren
dc.relation.ispartofPsychiatry Research (2024), vol. 331, 115614es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//16%2F2148/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//19%2F1698/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//RD21%2F0009%2F0025/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//17%2F31/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//18%2F41/
dc.relation.publisherversionhttps://doi.org/10.1016/j.psychres.2023.115614
dc.rights© 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFirst-episode psychosisen
dc.subjectLatent analysisen
dc.subjectLong-term trajectoriesen
dc.subjectPredictorsen
dc.subjectPsychopathological dimensionsen
dc.title20-Year trajectories of six psychopathological dimensions in patients with first-episode psychosis: could they be predicted?en
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication6cfdb372-fb89-4760-b1b8-404b0f0ae941
relation.isAuthorOfPublication.latestForDiscovery6cfdb372-fb89-4760-b1b8-404b0f0ae941

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