Motor skill learning modulates striatal extracellular vesicles' content in a mouse model of Huntington's disease

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dc.contributor.authorSolana-Balaguer, Júlia
dc.contributor.authorGarcía-Segura, Pol
dc.contributor.authorCampoy-Campos, Genís
dc.contributor.authorChicote-González, Almudena
dc.contributor.authorFernández Irigoyen, Joaquín
dc.contributor.authorSantamaría Martínez, Enrique
dc.contributor.authorPérez-Navarro, Esther
dc.contributor.authorMasana, Mercè
dc.contributor.authorAlberch, Jordi
dc.contributor.authorMalagelada, Cristina
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2024-10-18T12:00:59Z
dc.date.available2024-10-18T12:00:59Z
dc.date.issued2024-06-11
dc.date.updated2024-10-18T11:24:24Z
dc.description.abstractHuntington's disease (HD) is a neurological disorder caused by a CAG expansion in the Huntingtin gene (HTT). HD pathology mostly affects striatal medium-sized spiny neurons and results in an altered cortico-striatal function. Recent studies report that motor skill learning, and cortico-striatal stimulation attenuate the neuropathology in HD, resulting in an amelioration of some motor and cognitive functions. During physical training, extracellular vesicles (EVs) are released in many tissues, including the brain, as a potential means for inter-tissue communication. To investigate how motor skill learning, involving acute physical training, modulates EVs crosstalk between cells in the striatum, we trained wild-type (WT) and R6/1 mice, the latter with motor and cognitive deficits, on the accelerating rotarod test, and we isolated their striatal EVs. EVs from R6/1 mice presented alterations in the small exosome population when compared to WT. Proteomic analyses revealed that striatal R6/1 EVs recapitulated signaling and energy deficiencies present in HD. Motor skill learning in R6/1 mice restored the amount of EVs and their protein content in comparison to naïve R6/1 mice. Furthermore, motor skill learning modulated crucial pathways in metabolism and neurodegeneration. All these data provide new insights into the pathogenesis of HD and put striatal EVs in the spotlight to understand the signaling and metabolic alterations in neurodegenerative diseases. Moreover, our results suggest that motor learning is a crucial modulator of cell-to-cell communication in the striatum.en
dc.description.sponsorshipMinisterio de Ciencia e Innovación (#FPU18/00194, FPU21/02928, PID2020-119236RB-I00, PID2019-106447RB-I00, PID2021-124896OA-I000, PID2020-119386RB-I00, SAF2017-88812-R). Agència de Gestió d'Ajuts Universitaris i de Recerca (FI-B-00378). Michael J. Fox Foundation for Parkinson's Research (MJFF-000858, MJFF-000858). Horizon 2020 Framework Programme (863214).
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSolana-Balaguer, J., Garcia-Segura, P., Campoy-Campos, G., Chicote-González, A., Fernández-Irigoyen, J., Santamaría, E., Pérez-Navarro, E., Masana, M., Alberch, J., Malagelada, C. (2024). Motor skill learning modulates striatal extracellular vesicles' content in a mouse model of Huntington's disease. Cell Communication and Signaling, 22(1), 1-16. https://doi.org/10.1186/s12964-024-01693-9.
dc.identifier.doi10.1186/s12964-024-01693-9
dc.identifier.issn1478-811X
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/52326
dc.language.isoeng
dc.publisherBMC
dc.relation.ispartofCell Communication and Signaling (2024), vol. 22, núm. 321
dc.relation.projectIDinfo:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/863214/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119236RB-I00/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119386RB-I00/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-124896OA-I00/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-106447RB-I00/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-88812-R/ES/
dc.relation.publisherversionhttps://doi.org/10.1186/s12964-024-01693-9
dc.rights© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCortico-striatal activationen
dc.subjectExtracellular vesiclesen
dc.subjectHuntingto's diseaseen
dc.subjectMotor learningen
dc.subjectProteomicsen
dc.subjectStriatumen
dc.titleMotor skill learning modulates striatal extracellular vesicles' content in a mouse model of Huntington's diseaseen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication86d1b76e-4790-40b1-a3ec-72331c5c6199
relation.isAuthorOfPublicationabacfd17-2b93-4d99-bae2-52053d57401e
relation.isAuthorOfPublication.latestForDiscovery86d1b76e-4790-40b1-a3ec-72331c5c6199

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