Association of intrinsic capacity with incidence and mortality of cardiovascular disease: prospective study in UK Biobank

Ramírez Vélez, Robinson; Iriarte-Fernández, María; Santafé Rodrigo, Guzmán; Malanda Trigueros, Armando; Beard, John R.; García Hermoso, Antonio; Izquierdo Redín, Mikel

Publication:
Association of intrinsic capacity with incidence and mortality of cardiovascular disease: prospective study in UK Biobank

dc.contributor.author	Ramírez Vélez, Robinson
dc.contributor.author	Iriarte-Fernández, María
dc.contributor.author	Santafé Rodrigo, Guzmán
dc.contributor.author	Malanda Trigueros, Armando
dc.contributor.author	Beard, John R.
dc.contributor.author	García Hermoso, Antonio
dc.contributor.author	Izquierdo Redín, Mikel
dc.contributor.department	Ciencias de la Salud	es_ES
dc.contributor.department	Estadística, Informática y Matemáticas	es_ES
dc.contributor.department	Ingeniería Eléctrica, Electrónica y de Comunicación	es_ES
dc.contributor.department	Institute for Advanced Materials and Mathematics - INAMAT2	en
dc.contributor.department	Osasun Zientziak	eu
dc.contributor.department	Estatistika, Informatika eta Matematika	eu
dc.contributor.department	Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren	eu
dc.contributor.funder	Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa	es
dc.date.accessioned	2023-09-08T17:37:17Z
dc.date.available	2023-09-08T17:37:17Z
dc.date.issued	2023
dc.date.updated	2023-09-08T17:17:26Z
dc.description.abstract	Background: The World Health Organization proposed the concept of intrinsic capacity (IC; the composite of all the physical and mental capacities of the individual) as central for healthy ageing. However, little research has investigated the interaction and joint associations of IC with cardiovascular disease (CVD) incidence and CVD mortality in middle- and older-aged adults. Methods: Using data from 443 130 UK Biobank participants, we analysed seven biomarkers capturing the level of functioning of five domains of IC to calculate a total IC score (ranging from 0 [better IC] to +4 points [poor IC]). Associations between IC score and incidence of six long-term CVD conditions (hypertension, stroke/transient ischaemic attack stroke, peripheral vascular disease, atrial fibrillation/flutter, coronary artery disease and heart failure), and grouped mortality from these conditions were estimated using Cox proportional models, with a 1-year landmark analysis to triangulate the findings. Results: Over 10.6 years of follow-up, CVD morbidity grouped (n = 384 380 participants for the final analytic sample) was associated with IC scores (0 to +4): mean hazard ratio (HR) [95% confidence interval, CI] 1.11 [1.08–1.14], 1.20 [1.16–1.24], 1.29 [1.23–1.36] and 1.56 [1.45–1.59] in men (C-index = 0.68), and 1.17 [1.13–1.20], 1.30 [1.26–1.36], 1.52 [1.45–1.59] and 1.78 [1.67–1.89] in women (C-index = 0.70). In regard to mortality, our results indicated that the higher IC score (+4 points) was associated with a significant increase in subsequent CVD mortality (mean HR [95% CI]: 2.10 [1.81–2.43] in men [C-index = 0.75] and 2.29 [1.85–2.84] in women [C-index = 0.78]). Results of all sensitivity analyses by full sample, sex and age categories were largely consistent independent of major confounding factors (P < 0.001). Conclusions: IC deficit score is a powerful predictor of functional trajectories and vulnerabilities of the individual in relation to CVD incidence and premature death. Monitoring an individual's IC score may provide an early-warning system to initiate preventive efforts.	en
dc.description.sponsorship	This study was funded by Universidad Pública de Navarra.	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Ramírez-Vélez, R., Iriarte-Fernández, M., Santafé, G., Malanda, A., Beard, J. R., Garcia-Hermoso, A., Izquierdo, M. (2023) Association of intrinsic capacity with incidence and mortality of cardiovascular disease: prospective study in UK Biobank. Journal of Cachexia, Sarcopenia and Muscle (JCSM), 1-10. https://doi.org/10.1002/jcsm.13283.	en
dc.identifier.doi	10.1002/jcsm.13283
dc.identifier.issn	2190-5991
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/46255
dc.language.iso	eng	en
dc.publisher	Wiley	en
dc.relation.ispartof	Journal of Cachexia, Sarcopenia and Muscle (2023)	en
dc.relation.publisherversion	https://doi.org/10.1002/jcsm.13283
dc.rights	© 2023 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.	en
dc.rights.accessRights	Acceso abierto / Sarbide irekia	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/
dc.subject	Biological ageing	en
dc.subject	Biomarkers	en
dc.subject	Incident pathologies	en
dc.subject	Intrinsic capacity	en
dc.subject	Mortality	en
dc.title	Association of intrinsic capacity with incidence and mortality of cardiovascular disease: prospective study in UK Biobank	en
dc.type	Artículo / Artikulua	es
dc.type	info:eu-repo/semantics/article	en
dc.type.version	Versión publicada / Argitaratu den bertsioa	es
dc.type.version	info:eu-repo/semantics/publishedVersion	en
dspace.entity.type	Publication
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