Gender-dependent deregulation of linear and circular RNA variants of homer1 in the entorhinal cortex of Alzheimer’s disease

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dc.contributor.authorUrdánoz Casado, Amaya
dc.contributor.authorSánchez Ruiz de Gordoa, Javier
dc.contributor.authorRobles Solano, Maitane
dc.contributor.authorAcha Santamaría, Blanca
dc.contributor.authorRoldán, Miren
dc.contributor.authorZelaya Huerta, María Victoria
dc.contributor.authorBlanco Luquin, Idoia
dc.contributor.authorMendióroz Iriarte, Maite
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernuaes
dc.date.accessioned2022-01-12T08:17:19Z
dc.date.available2022-01-12T08:17:19Z
dc.date.issued2021
dc.description.abstractThe HOMER1 gene is involved in synaptic plasticity, learning and memory. Recent studies show that circular RNA derived from HOMER1 (circHOMER1) expression is altered in some Alzheimer’s disease (AD) brain regions. In addition, HOMER1 messenger (mRNA) levels have been associated with β-Amyloid (Aβ) deposits in brain cortical regions. Our aim was to measure the expression levels of HOMER1 circRNAs and their linear forms in the human AD entorhinal cortex. First, we showed downregulation of HOMER1B/C and HOMER1A mRNA and hsa_circ_0006916 and hsa_circ_0073127 levels in AD female cases compared to controls by RT-qPCR. A positive correlation was observed between HOMER1B/C, HOMER1A mRNA, and hsa_circ_0073128 with HOMER1B/C protein only in females. Global average area of Aβ deposits in entorhinal cortex samples was negatively correlated with HOMER1B/C, HOMER1A mRNA, and hsa_circ_0073127 in both genders. Furthermore, no differences in DNA methylation were found in two regions of HOMER1 promoter between AD cases and controls. To sum up, we demonstrate that linear and circular RNA variants of HOMER1 are downregulated in the entorhinal cortex of female patients with AD. These results add to the notion that HOMER1 and its circular forms could be playing a female-specific role in the pathogenesis of AD.en
dc.description.sponsorshipThis work was supported by the Spanish Government through grants from the Institute of Health Carlos III (FIS PI20/01701). In addition, A.U.-C. received two grants 'Doctorados industriales 2018–2020' and 'Contrato predoctoral en investigación en ciencias y tecnologías de la salud en el periodo 2019–2022', both of them founded by the Government of Navarra. B.A. is supported by a PFIS fellowship from the Spanish Government (FI18/00150) and M.M. received a grant 'Programa de intensificación' (LCF/PR/PR15/51100006) funded by Fundación Bancaria 'la Caixa' and Fundación Caja-Navarra and 'Contrato de intensificación' from the Institute of Health Carlos III (INT19/00029).en
dc.format.extent15 p.
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.identifier.doi10.3390/ijms22179205
dc.identifier.issn1422-0067
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/41747
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofInternational Journal of Molecular Sciences, 22 (17), 9205en
dc.relation.publisherversionhttps://doi.org/10.3390/ijms22179205
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAlzheimer's diseaseen
dc.subjectEntorhinal cortexen
dc.subjectHOMER1en
dc.subjectSleep deprivationen
dc.subjectcircRNAen
dc.subjectmRNAen
dc.subjectCalciumen
dc.subjectSynapsesen
dc.subjectAmyloid betaen
dc.subjectGenderen
dc.subjectFemaleen
dc.titleGender-dependent deregulation of linear and circular RNA variants of homer1 in the entorhinal cortex of Alzheimer’s diseaseen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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relation.isAuthorOfPublication26498cd1-19ac-4305-836e-518f311f361c
relation.isAuthorOfPublicationd09deda5-8d94-42e0-97f0-b32e34571988
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relation.isAuthorOfPublication.latestForDiscoveryc0cb79d9-6664-4b47-bcd1-b7cb133d224e

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