Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trial

Simple item page
dc.contributor.authorCasas Herrero, Álvaro
dc.contributor.authorSáez de Asteasu, Mikel L.
dc.contributor.authorAntón Rodrigo, Iván
dc.contributor.authorSánchez Sánchez, Juan Luis
dc.contributor.authorMontero Odasso, Manuel
dc.contributor.authorMarín Epelde, Itxaso
dc.contributor.authorRamón Espinoza, Fernanda
dc.contributor.authorZambom Ferraresi, Fabrício
dc.contributor.authorPetidier Torregrosa, Roberto
dc.contributor.authorElexpuru Estomba, Jaione
dc.contributor.authorÁlvarez Bustos, Alejandro
dc.contributor.authorGalbete Jiménez, Arkaitz
dc.contributor.authorMartínez Velilla, Nicolás
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernuaes
dc.date.accessioned2022-04-07T12:10:19Z
dc.date.available2022-04-07T12:10:19Z
dc.date.issued2022
dc.description.abstractBackground: physical exercise is an effective strategy for preserving functional capacity and improving the symptoms of frailty in older adults. In addition to functional gains, exercise is considered to be a cornerstone for enhancing cognitive function in frail older adults with cognitive impairment and dementia. We assessed the effects of the Vivifrail exercise intervention for functional capacity, cognition, and well-being status in community-dwelling older adults. Methods: in a multicentre randomized controlled trial conducted in three tertiary hospitals in Spain, a total of 188 older patients with mild cognitive impairment or mild dementia (aged >75 years) were randomly assigned to an exercise intervention (n = 88) or a usual-care, control (n = 100) group. The intervention was based on the Vivifrail tailored multicomponent exercise programme, which included resistance, balance, flexibility (3 days/week), and gait-retraining exercises (5 days/week) and was performed for three consecutive months (http://vivifrail.com). The usual-care group received habitual outpatient care. The main endpoint was change in functional capacity from baseline to 1 and 3 months, assessed with the Short Physical Performance Battery (SPPB). Secondary endpoints were changes in cognitive function and handgrip strength after 1 and 3 months, and well-being status, falls, hospital admission rate, visits to the emergency department, and mortality after 3 months. Results: the Vivifrail exercise programme provided significant benefits in functional capacity over usual-care. The mean adherence to the exercise sessions was 79% in the first month and 68% in the following 2 months. The intervention group showed a mean increase (over the control group) of 0.86 points on the SPPB scale (95% confidence interval [CI] 0.32, 1.41 points; P < 0.01) after 1 month of intervention and 1.40 points (95% CI 0.82, 1.98 points; P < 0.001) after 3 months. Participants in the usual-care group showed no significant benefit in functional capacity (mean change of −0.17 points [95% CI −0.54, 0.19 points] after 1 month and −0.33 points [95% CI −0.70, 0.04 points] after 3 months), whereas the exercise intervention reversed this trend (0.69 points [95% CI 0.29, 1.09 points] after 1 month and 1.07 points [95% CI 0.63, 1.51 points] after 3 months). Exercise group also obtained significant benefits in cognitive function, muscle function, and depression after 3 months over control group (P < 0.05). No between-group differences were obtained in other secondary endpoints (P > 0.05). Conclusions: the Vivifrail exercise training programme is an effective and safe therapy for improving functional capacity in community-dwelling frail/prefrail older patients with mild cognitive impairment or mild dementia and also seems to have beneficial effect on cognition, muscle function, and mood status.en
dc.description.sponsorshipThis study has been funded by a Gobierno de Navarra projectgrant and fondos FEDER (Resolución 426/2016, del 30 deseptiembre 28/16). Mikel Izquierdo is funded by a researchgrant PI17/01814 of the Ministerio de Economía, Industria yCompetitividad (ISCIII, FEDER).en
dc.format.extent10 p.
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/msworden
dc.identifier.doi10.1002/jcsm.12925
dc.identifier.issn2190-5991
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/42665
dc.language.isoengen
dc.publisherWiley Open Access
dc.relation.ispartofJournal of Cachexia, Sarcopenia and Muscle. Vol. 13 (2), 2022, p. 884-893en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01814/ES/
dc.relation.publisherversionhttps://doi.org/10.1002/jcsm.12925
dc.rights© 2022 The Authors. Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFallsen
dc.subjectFrailtyen
dc.subjectFunctional capacityen
dc.subjectMulticomponent exercise programmeen
dc.titleEffects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trialen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication67dfcd6b-a693-478c-98be-f4b7c5bed42d
relation.isAuthorOfPublicationed9d4f53-b734-4d6e-b1b9-188a148f9a13
relation.isAuthorOfPublication3e6a0af4-f362-4385-99bb-e24e79a7a539
relation.isAuthorOfPublication4bb570ab-10a2-4b9a-8ee8-893bbd090df6
relation.isAuthorOfPublication6185f43e-9015-4343-a2f5-2c6ad8ed869a
relation.isAuthorOfPublicationef73585d-4750-4f56-9d4f-0d759232dbca
relation.isAuthorOfPublication.latestForDiscovery67dfcd6b-a693-478c-98be-f4b7c5bed42d

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Casas_EffectsVivifrail.pdf
Size:
2.11 MB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
Casas_EffectsVivifrail_MatCompl.doc
Size:
231 KB
Format:
Microsoft Word
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista DCS - OZS Aldizkari artikuluak
Artículos de revista - Aldizkari artikuluak