Reference values for handgrip strength and their association with intrinsic capacity domains among older adults

dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.authorCorrea Bautista, Jorge Enrique
dc.contributor.authorGarcía Hermoso, Antonio
dc.contributor.authorCano Gutiérrez, Carlos Alberto
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2019-11-25T13:16:02Z
dc.date.available2019-11-25T13:16:02Z
dc.date.issued2019
dc.description.abstractObjective The purposes of this study were three-fold: (i) to describe handgrip strength in older individuals aged >= 60 years in Colombia; (ii) to identify sex-specific and age-specific muscle weakness cut-off points in older adults; and (iii) to determine the odds of adverse events for each of the intrinsic capacity domains for individuals with handgrip strength greater than the muscle weakness cut-off points, as compared with their weaker counterparts. Methods A cross-sectional study was conducted in Colombia, among 5237 older adults aged >= 60 years old (58.5% women, 70.5 +/- 7.8 years), according to 'SABE Survey 2015'. Handgrip strength data were obtained with a Takei dynamometer. Sociodemographic variables, five domains of intrinsic capacity (i.e. locomotion, vitality, cognition, psychological, and sensory), and medical conditions were assessed and analyzed. Adjustments variables were age, ethnicity, socio-economic status, urbanicity, body mass index, smoking status, alcohol intake, drug use, physical activity, and co-morbid chronic diseases. Sex-stratified analyses were conducted with logistic regression models. Results Handgrip strength was greater among men than among women (26.7 +/- 8.5 vs. 16.7 +/- 5.7 kg, respectively, P < 0.001) at all ages. Weak handgrip strength cut-off points ranged from 17.4 to 8.6 and from 10.1 to 4.9 in men and women, respectively. Overall, participants with optimal handgrip strength had better intrinsic capacity [in men, odds ratio (OR) = 0.62, 95% confidence interval (CI) 0.53 to 0.71; P < 0.001; and in women, OR = 0.79, 95% CI 0.68 to 0.92; P = 0.002] than their weaker counterparts. Also, men with optimal handgrip strength had a lower risk of hospitalization (OR = 0.47, 95% CI 0.29 to 0.78; P = 0.004) than their weaker counterparts. Conclusions This study is the first to describe handgrip strength values and cut-off points for muscle weakness among a nationally representative sample of Colombian older adults by age and sex. After categorizing older adults as weak or not weak based on the handgrip cut-off points, non-weakness was associated with a decreased odds of intrinsic capacity impairments. These cut-off points may be good candidates for clinical assessment of risks to physical and mental health in older Colombian adults.en
dc.description.sponsorshipThe SABE study is supported by a fund (2013, no. 764) from the Colciencias y Ministerio de Salud y la Protección Social de Colombia. Mikel Izquierdo is funded by ISCIII and Fondos FEDER (PI17/01814).en
dc.format.extent9 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1002/jcsm.12373
dc.identifier.issn2190-5991
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/35457
dc.language.isoengen
dc.publisherWileyen
dc.relation.ispartofJournal of Cachexia Sarcopenia and Muscle, 2019, 10: 278-286en
dc.relation.publisherversionhttps://doi.org/10.1002/jcsm.12373
dc.rights© 2019 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectSkeletal muscleen
dc.subjectHandgripen
dc.subjectOlder adultsen
dc.subjectLocomotionen
dc.subjectVitalityen
dc.subjectCognitionen
dc.subjectMental healthen
dc.titleReference values for handgrip strength and their association with intrinsic capacity domains among older adultsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationd0c2c11e-01d0-46ff-93b4-36b11beaf269
relation.isAuthorOfPublicatione84ae68a-fa4a-4e00-be27-bedfffc8612e
relation.isAuthorOfPublicationef73585d-4750-4f56-9d4f-0d759232dbca
relation.isAuthorOfPublication.latestForDiscoveryd0c2c11e-01d0-46ff-93b4-36b11beaf269

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