Association between body shape index and arterial stiffness: results of the EVasCu study and a meta-analysis

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dc.contributor.authorSaz-Lara, Alicia
dc.contributor.authorCavero-Redondo, Iván
dc.contributor.authorMoreno-Herráiz, Nerea
dc.contributor.authorRescalvo-Fernández, Elena
dc.contributor.authorBerlanga-Macías, Carlos
dc.contributor.authorMedrano Echeverría, María
dc.contributor.authorFuentes Chacón, Rosa María
dc.contributor.authorPascual-Morena, Carlos
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2025-02-20T08:08:15Z
dc.date.issued2024-10-28
dc.date.updated2025-02-20T07:52:26Z
dc.description.abstractObjective: The aim of this study was to analyse the association between body shape index (ABSI) and arterial stiffness in healthy subjects using data from the EVasCu study. In addition, a meta-analysis was performed to compare the association between ABSI and central, peripheral and systemic arterial stiffness in the general population. Methods: The EVasCu study included 390 healthy subjects. ABSI was calculated from waist circumference, body mass index and height, and arterial stiffness was assessed with aortic pulse wave velocity (a-PWv) and cardio-ankle vascular index (CAVI). A meta-analysis of previous studies, including data from the EVasCu study, was performed to obtain pooled estimates of correlation coefficients (r) and their respective 95% confidence intervals (95% CIs) for the association between ABSI and central, peripheral and systemic arterial stiffness. In addition, pooled OR estimates and their 95% CIs were calculated. Results: In the EVasCu study, the correlation coefficient estimate was 0.458 (p < 0.01) for the association of a-PWv and ABSI and 0.408 (p < 0.01) for the association of CAVI and ABSI. In the meta-analysis, the pooled correlation coefficient estimate was 0.22 (95% CIs: 0.16, 0.28) for central arterial stiffness and ABSI, 0.21 (95% CIs: 0.14, 0.28) for peripheral arterial stiffness and ABSI, and 0.28 (95% CI: 0.21, 0.3) for systemic arterial stiffness and ABSI. When pooled ORs were calculated, the pooled OR estimate was 2.12 (95% CIs: 1.68, 2.56) for central arterial stiffness and ABSI, 2.21 (95% CIs: 1.81, 2.60) for peripheral arterial stiffness and ABSI, and 2.99 (95% CIs: 2.14, 3.85) for systemic arterial stiffness and ABSI. Conclusion: Based on both the results obtained in the EVasCu study and the meta-analysis, there is a positive association between ABSI and arterial stiffness, both in healthy subjects and in participants with comorbidities. For each unit of cm/kg/m²/m increase in ABSI, the risk of arterial stiffness increased by 112% for central arterial stiffness, 121% for peripheral arterial stiffness, and 199% for systemic arterial stiffness. However, further research is needed in this field of knowledge.en
dc.description.sponsorshipThis study was funded by 42nd edition of the nursing award of the University Pontificia Comillas and Escuela de Enfermeria y Fisioterapia San Juan de Dios, and co-funded by the European Union (ERDF/ESF) and by the Carvascare Research Group from the Universidad de Castilla-La Mancha (2023-GRIN-34459).
dc.embargo.lift2025-04-28
dc.embargo.terms2025-04-28
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSaz-Lara, A., Cavero-Redondo, I., Moreno-Herráiz, N., Rescalvo-Fernández, E., Berlanga-Macías, C., Medrano, M., Fuentes Chacón, R. M., Pascual-Morena, C. (2024). Association between body shape index and arterial stiffness: results of the EVasCu study and a meta-analysis. International Journal of Obesity. 49, 554-563. https://doi.org/10.1038/s41366-024-01663-8
dc.identifier.doi10.1038/s41366-024-01663-8
dc.identifier.issn0307-0565
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/53508
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.ispartofInternational Journal of Obesity 49, 554-563
dc.relation.publisherversionhttps://doi.org/10.1038/s41366-024-01663-8
dc.rights© 2024, The Author(s), under exclusive licence to Springer Nature Limited
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectBody shape indexen
dc.subjectArterial stiffnessen
dc.subjectPulse wave velocityen
dc.subjectCardio-ankle vascular indexen
dc.subjectAdult populationen
dc.titleAssociation between body shape index and arterial stiffness: results of the EVasCu study and a meta-analysisen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication304856ca-cc85-4094-8ca3-b17f4c5f33de
relation.isAuthorOfPublication.latestForDiscovery304856ca-cc85-4094-8ca3-b17f4c5f33de

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