PD1 signal transduction pathways in T cells

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dc.contributor.authorArasanz Esteban, Hugo
dc.contributor.authorGato Cañas, María
dc.contributor.authorZuazo Ibarra, Miren
dc.contributor.authorIbañez Vea, María
dc.contributor.authorBreckpot, Karine
dc.contributor.authorKochan, Grazyna
dc.contributor.authorEscors Murugarren, David
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernuaes
dc.date.accessioned2022-08-08T11:34:49Z
dc.date.available2022-08-08T11:34:49Z
dc.date.issued2017
dc.date.updated2022-08-08T11:05:17Z
dc.description.abstractThe use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating high efficacies and low toxicities. Despite all the recent advances, very little is yet known on the molecular intracellular signaling pathways regulated by either PD-L1 or PD1. Here we review the current knowledge on PD1-dependent intracellular signaling pathways, and the consequences of disrupting PD1 signal transduction.en
dc.description.sponsorshipMGC is funded by a Government of Navarre PhD fellowship (BMED 033-2014); MZ is funded by a Gobierno de Navarra Project grant (GN 33/14) and a ‘Precipita’ crowdfunding project grant from Fundación Española para la Ciencia y la Tecnología (FECYT). MIV is funded by a Sara Borrel post-doctoral fellowship. DE is funded by a 'Miguel Servet' Fellowship (CP12/03114) from the Instituto de Salud Carlos III (ISCIII), Spain. GK is funded by a ‘Proyecto Tractor ProCel’ from the Government of Navarre. The authors gratefully acknowledge the ‘Sandra Ibarra’ Foundation, the ‘Navarrese Association against Breast Cancer’ (SARAY), ‘Caixa Foundation’ and ISCIII (FIS. PI14/00579 project grant) for their financial support.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationArasanz, H.; Gato-Cañas, M.; Zuazo, M.; Ibáñez-Vea, M.; Breckpot, K.; Kochan, G.; Escors, D.. (2017). PD1 signal transduction pathways in T cells. Oncotarget. 8,31, pp. 51936-51945en
dc.identifier.doi10.18632/oncotarget
dc.identifier.issn1949-2553
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/43708
dc.language.isoengen
dc.publisherImpact Journalsen
dc.relation.ispartofOncotarget, 2017, 8 (31), pp. 51936-51945en
dc.relation.publisherversionhttps://doi.org/10.18632/oncotarget
dc.rights© Arasanz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subjectPD-L1en
dc.subjectPDL1en
dc.subjectPD1en
dc.subjectB7-H1en
dc.subjectCanceren
dc.titlePD1 signal transduction pathways in T cellsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication193d800d-c38c-4627-b9d8-d29435d8214c
relation.isAuthorOfPublicationf96114c2-9fc5-4886-ab9a-4804f14aa9c6
relation.isAuthorOfPublication.latestForDiscovery193d800d-c38c-4627-b9d8-d29435d8214c

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