Publication: Encapsulation of fluorinated nanoparticles as potential off/on probe for 19F MRI
Consultable a partir de
Date
2017
Authors
Pérez Jiménez, Elena
Director
Publisher
Acceso abierto / Sarbide irekia
Trabajo Fin de Máster / Master Amaierako Lana
Project identifier
Abstract
The present work deals with the synthesis of fluorine labeled gold nanoparticles followed by their encapsulation in gelatin nanoparticles. The choice of gelatin is based on its role as substrate for gelatinases MMP enzymes (MMP-2/9). Hence, our hypothesis is that when our fluorine labeled NPs are encapsulated in gelatin the 19F MRI signal would be OFF. The disassembly of the gelatin NPs triggered by its digestion by MMPs should lead to the turning ON of the signal.
Keywords
Encapsulation, Nanoparticles
Department
Faculty/School
Escuela Técnica Superior de Ingenieros Agrónomos / Nekazaritza Ingeniarien Goi Mailako Eskola Teknikoa
Degree
Máster Universitario en Química Sintética e Industrial por la Universidad de Valladolid; la Universidad del País Vasco / Euskal Herriko Unibertsitatea y la Universidad Pública de Navarra, Kimika Sintetiko eta Industrialeko Masterra Valladolideko Unibertsitatean; Universidad del País Vasco / Euskal Herriko Unibertsitatea eta Nafarroako Unibertsitate Publikoa
Doctorate program
Editor version
Funding entities
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