Comparative lipidomic profiling in adolescents with obesity and adolescents with type 1 diabetes

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dc.contributor.authorGarcía Hermoso, Antonio
dc.contributor.authorHuerta Uribe, Nidia
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.authorGonzález-Ruíz, Katherine
dc.contributor.authorCorrea Bautista, Jorge Enrique
dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2025-03-24T18:11:51Z
dc.date.issued2025-01-18
dc.date.updated2025-03-24T17:57:21Z
dc.description.abstractObjective: Both adolescents with obesity and those with type 1 diabetes (T1D) exhibit alterations in lipid profiles, but direct comparisons are limited. Comparing lipidomic profiles between obese individuals and those with T1D is crucial for identifying specific metabolic markers, informing tailored interventions, and advancing precision medicine strategies for these distinct populations. The aim of the study was to compare lipidomic profiles between adolescents with obesity and those with T1D, and to analyze associations between metabolites and clinical parameters. Methods: We included 156 adolescents aged 11–18 years (59.6% girls) from the HEPAFIT (n=114, obesity) and Diactive-1 Cohort (n=42, T1D) studies. Clinical measures included anthropometrics, body composition, lipids, liver enzymes, glucose, and HbA1c. Lipidomic analysis of 277 serum/ plasma metabolites used UHPLC-MS. Results: Distinct lipid profiles were seen, with higher diglycerides, triglycerides, and certain phosphatidylinositols in the obesity group, while phosphatidylcholines, phosphatidylethanolamines, cholesterol esters, sphingomyelins, and ceramides were elevated in T1D. Triglycerides acyl chain lengths and saturation levels also varied. Multivariate analysis identified seven metabolites –PC(O-18:1/18:1), PC(O-18:1/22:4), PE(O-16:0/18:1), PE(18:2e/22:6), PC(40:1), PC(O22:1/20:4), and PE(P-18:0/18:1)– significantly associated with clinical parameters. Conclusions: Distinct lipid profiles were observed among adolescents with obesity and T1D in the study, emphasizing the importance of understanding specific metabolite associations with clinical parameters for more precise health management.en
dc.description.sponsorshipThe HEPAFIT Study was carried out with the financial support of Universidad del Rosario. The content of this paper reflects the author's views alone, and the Colombian Community or the Universidad del Rosario is not liable for any use that may be made of the information contained herein. The Diactive-1 study was funded by grant PI21/01238 from the Instituto de Salud Carlos III (Spain).
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dc.format.mimetypeapplication/msworden
dc.identifier.citationGarcía-Hermoso, A., Huerta-Uribe, N., Izquierdo, M., González-Ruíz, K., Correa-Bautista, J. E., Ramírez-Vélez, R. (2025) Comparative lipidomic profiling in adolescents with obesity and adolescents with type 1 diabetes. Current Problems in Cardiology, 50(3), 1-9. https://doi.org/10.1016/j.cpcardiol.2025.102991.
dc.identifier.doi10.1016/j.cpcardiol.2025.102991
dc.identifier.issn0146-2806
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/53803
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofCurrent Problems in Cardiology 50(3), 2025, 102991
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F01238/ES/
dc.relation.publisherversionhttps://doi.org/10.1016/j.cpcardiol.2025.102991
dc.rights© 2025 The Authors. This is an open access article under the CC BY license.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdolescent obesityen
dc.subjectBiomarkeren
dc.subjectLipid metabolismen
dc.subjectInsulin resistanceen
dc.subjectDiabetesen
dc.titleComparative lipidomic profiling in adolescents with obesity and adolescents with type 1 diabetesen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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