Relative handgrip strength diminishes the negative effects of excess adiposity on dependence in older adults: a moderation analysis
| dc.contributor.author | Ramírez Vélez, Robinson | |
| dc.contributor.author | Pérez Sousa, Miguel A. | |
| dc.contributor.author | García Hermoso, Antonio | |
| dc.contributor.author | Zambom Ferraresi, Fabrício | |
| dc.contributor.author | Martínez Velilla, Nicolás | |
| dc.contributor.author | López Sáez de Asteasu, Mikel | |
| dc.contributor.author | Cano Gutiérrez, Carlos Alberto | |
| dc.contributor.author | Rincón Pabón, David | |
| dc.contributor.author | Izquierdo Redín, Mikel | |
| dc.contributor.department | Ciencias de la Salud | es_ES |
| dc.contributor.department | Osasun Zientziak | eu |
| dc.contributor.funder | Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa | es |
| dc.date.accessioned | 2020-07-06T08:41:19Z | |
| dc.date.available | 2020-07-06T08:41:19Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | The adverse effects of fat mass on functional dependence might be attenuated or worsened, depending on the level of muscular strength. The aim of this study was to determine (i) the detrimental effect of excess adiposity on dependence in activities of daily living (ADL), and (ii) whether relative handgrip strength (HGS) moderates the adverse effect of excess adiposity on dependence, and to provide the threshold of relative HGS from which the adverse effect could be improved or worsened. A total of 4169 participants (69.3 +/- 7.0 years old) from 244 municipalities were selected following a multistage area probability sampling design. Measurements included anthropometric/adiposity markers (weight, height, body mass index, waist circumference, and waist-to-height ratio (WHtR)), HGS, sarcopenia 'proxy' (calf circumference), and ADL (Barthel Index scale). Moderation analyses were performed to identify associations between the independent variable (WHtR) and outcomes (dependence), as well as to determine whether relative HGS moderates the relationship between excess adiposity and dependence. The present study demonstrated that (i) the adverse effect of having a higher WHtR level on dependence in ADL was moderated by relative HGS, and (ii) two moderation thresholds of relative HGS were estimated: 0.35, below which the adverse effect of WHtR levels on dependency is aggravated, and 0.62, above which the adverse effect of fat on dependency could be improved. Because muscular strength represents a critically important and modifiable predictor of ADL, and the increase in adiposity is inherent in aging, our results underscore the importance of an optimal level of relative HGS in the older adult population. | en |
| dc.description.sponsorship | This study is part of a larger project that has been funded by a Colciencias y Ministerio de Salud y la Proteccion Social de Colombia (The SABE Study ID 2013, no. 764). M.I. is also funded in part by a research grant PI17/01814 of the Ministerio de Economia, Industria y Competitividad (ISCIII, FEDER). A.G.-H. is a Miguel Servet Fellow (Instituto de Salud Carlos III-FSE-CP18/0150). R.R.-V. was funded in part by a Postdoctoral Fellowship Resolution ID 420/2019 of the Universidad Publica de Navarra. | en |
| dc.format.extent | 11 p. | |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | 10.3390/jcm9041152 | |
| dc.identifier.issn | 2077-0383 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/37330 | |
| dc.language.iso | eng | en |
| dc.publisher | MDPI | en |
| dc.relation.ispartof | Journal of Clinical Medicine, 2020, 9(4), 1152 | en |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MTM2017-82553-R/ES/ | |
| dc.relation.publisherversion | https://doi.org/10.3390/jcm9041152 | |
| dc.rights | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Fat mass | en |
| dc.subject | Obesity | en |
| dc.subject | Muscle strength | en |
| dc.subject | Physical function | en |
| dc.subject | Functional dependence | en |
| dc.title | Relative handgrip strength diminishes the negative effects of excess adiposity on dependence in older adults: a moderation analysis | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
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