Schizophrenia and hospital admissions for cardiovascular events in a large population: the APNA study

Guillén Aguinaga, Sara; Brugos Larumbe, Antonio; Guillén Aguinaga, Laura; Ortuño, Felipe; Guillén Grima, Francisco; Forga, Lluís; Aguinaga Ontoso, Inés

Publication:
Schizophrenia and hospital admissions for cardiovascular events in a large population: the APNA study

dc.contributor.author	Guillén Aguinaga, Sara
dc.contributor.author	Brugos Larumbe, Antonio
dc.contributor.author	Guillén Aguinaga, Laura	es_ES
dc.contributor.author	Ortuño, Felipe	es_ES
dc.contributor.author	Guillén Grima, Francisco
dc.contributor.author	Forga, Lluís	es_ES
dc.contributor.author	Aguinaga Ontoso, Inés
dc.contributor.department	Ciencias de la Salud	es_ES
dc.contributor.department	Osasun Zientziak	eu
dc.date.accessioned	2022-04-12T10:44:02Z
dc.date.available	2022-04-12T10:44:02Z
dc.date.issued	2022
dc.description.abstract	(1) Background: patients with schizophrenia have higher mortality, with cardiovascular diseases being the first cause of mortality. This study aims to estimate the excess risk of hospital admission for cardiovascular events in schizophrenic patients, adjusting for comorbidity and risk factors. (2) Methods: the APNA study is a dynamic prospective cohort of all residents in Navarra, Spain. A total of 505,889 people over 18 years old were followed for five years. The endpoint was hospital admissions for a cardiovascular event. Direct Acyclic Graphs (DAG) and Cox regression were used. (3) Results: schizophrenic patients had a Hazard Ratio (HR) of 1.414 (95% CI 1.031–1.938) of hospital admission for a cardiovascular event after adjusting for age, sex, hypertension, type 2 diabetes, dyslipidemia, smoking, low income, obesity, antecedents of cardiovascular disease, and smoking. In non-adherent to antipsychotic treatment schizophrenia patients, the HR was 2.232 (95% CI 1.267–3.933). (4) Conclusions: patients with schizophrenia have a higher risk of hospital admission for cardiovascular events than persons with the same risk factors without schizophrenia. Primary care nursing interventions should monitor these patients and reduce cardiovascular risk factors.	en
dc.description.sponsorship	Menarini supported this study with an unconditional sponsored research grant. DM2-12-2017.	en
dc.format.extent	9 p.
dc.format.mimetype	application/pdf	en
dc.format.mimetype	application/zip	en
dc.identifier.doi	10.3390/jcdd9010025
dc.identifier.issn	2308-3425
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/42757
dc.language.iso	eng	en
dc.publisher	MDPI	en
dc.relation.ispartof	Journal of Cardiovascular Development and Disease, 9 (1), p. 25, 2022	en
dc.relation.publisherversion	https://doi.org/10.3390/jcdd9010025
dc.rights	© 2022 by the authors. Creative Commons Attribution 4.0 International	en
dc.rights.accessRights	info:eu-repo/semantics/openAccess	en
dc.rights.accessRights	Acceso abierto / Sarbide irekia	es
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject	Cardiovascular	en
dc.subject	Hospital admissions	en
dc.subject	Prospective cohort	en
dc.subject	Schizophrenia	en
dc.title	Schizophrenia and hospital admissions for cardiovascular events in a large population: the APNA study	en
dc.type	info:eu-repo/semantics/article	en
dc.type	Artículo / Artikulua	es
dc.type.version	info:eu-repo/semantics/publishedVersion	en
dc.type.version	Versión publicada / Argitaratu den bertsioa	es
dspace.entity.type	Publication
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