Nutritional interventions with bacillus coagulans improved glucose metabolism and hyperinsulinemia in mice with acute intermittent porphyria

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dc.contributor.authorLongo, Miriam
dc.contributor.authorJericó, Daniel
dc.contributor.authorCórdoba, Karol M.
dc.contributor.authorRiezu Boj, José I.
dc.contributor.authorUrtasun Alonso, Raquel
dc.contributor.authorSolares, Isabel
dc.contributor.authorSampedro, Ana
dc.contributor.authorCollantes, María
dc.contributor.authorPeñuelas, Iván
dc.contributor.authorMoreno Aliaga, María J.
dc.contributor.authorÁvila, Matías A.
dc.contributor.authorDi Pierro, Elena
dc.contributor.authorBarajas Vélez, Miguel Ángel
dc.contributor.authorMilagro Yoldi, F. I.
dc.contributor.authorDongiovanni, Paola
dc.contributor.authorFontanellas, Antonio
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2023-09-28T15:37:10Z
dc.date.available2023-09-28T15:37:10Z
dc.date.issued2023
dc.date.updated2023-09-28T14:49:07Z
dc.description.abstractAcute intermittent porphyria (AIP) is a metabolic disorder caused by mutations in the porphobilinogen deaminase (PBGD) gene, encoding the third enzyme of the heme synthesis pathway. Although AIP is characterized by low clinical penetrance (~1% of PBGD mutation carriers), patients with clinically stable disease report chronic symptoms and frequently show insulin resistance. This study aimed to evaluate the beneficial impact of nutritional interventions on correct carbohydrate dysfunctions in a mouse model of AIP that reproduces insulin resistance and altered glucose metabolism. The addition of spores of Bacillus coagulans in drinking water for 12 weeks modified the gut microbiome composition in AIP mice, ameliorated glucose tolerance and hyperinsulinemia, and stimulated fat disposal in adipose tissue. Lipid breakdown may be mediated by muscles burning energy and heat dissipation by brown adipose tissue, resulting in a loss of fatty tissue and improved lean/fat tissue ratio. Probiotic supplementation also improved muscle glucose uptake, as measured using Positron Emission Tomography (PET) analysis. In conclusion, these data provide a proof of concept that probiotics, as a dietary intervention in AIP, induce relevant changes in intestinal bacteria composition and improve glucose uptake and muscular energy utilization. Probiotics may offer a safe, efficient, and cost-effective option to manage people with insulin resistance associated with AIP.en
dc.description.sponsorshipThis research was supported in part by grants from the Spanish Institute of Health Carlos III (FIS) cofunded by the European Union (ERDF/ESF, “A way to make Europe”/“Investing in your future” (grant number PI21/00546) and the Spanish Fundación Mutua Madrileña de Investigación Médica.en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.identifier.citationLongo, M., Jericó, D., Córdoba, K. M., Riezu-Boj, J. I., Urtasun, R., Solares, I., Sampedro, A., Collantes, M., Peñuelas, I., Moreno-Aliaga, M. J., Ávila, M. A., Pierro, E. D., Barajas, M., Milagro, F. I., Dongiovanni, P., Fontanellas, A. (2023) Nutritional interventions with bacillus coagulans improved glucose metabolism and hyperinsulinemia in mice with acute intermittent porphyria. International Journal of Molecular Sciences, 24(15), 1-19. https://doi.org/10.3390/ijms241511938.en
dc.identifier.doi10.3390/ijms241511938
dc.identifier.issn1661-6596
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/46417
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofInternational Journal of Molecular Sciences 2023, 24(15), 11938en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F00546/ES/
dc.relation.publisherversionhttps://doi.org/10.3390/ijms241511938
dc.rights© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGlucose homeostasisen
dc.subjectGut microbiomeen
dc.subjectHepatic porphyriaen
dc.subjectInsulin resistanceen
dc.subjectMetabolic diseaseen
dc.subjectNutritional interventionen
dc.subjectProbioticsen
dc.titleNutritional interventions with bacillus coagulans improved glucose metabolism and hyperinsulinemia in mice with acute intermittent porphyriaen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication64ffa81f-666a-4086-80fb-a1f290644a67
relation.isAuthorOfPublication2e998efa-ca5a-491e-9e7f-a8fbbd0094ce
relation.isAuthorOfPublicationfc55179f-8b60-40ec-9057-a22de0f05e35
relation.isAuthorOfPublication.latestForDiscovery64ffa81f-666a-4086-80fb-a1f290644a67

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