CITA GO-ON study: a community based multidomain lifestyle intervention to prevent cognitive decline: protocol design and recruitment process

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dc.contributor.authorTainta, Mikel
dc.contributor.authorEcay-Torres, Mirian
dc.contributor.authorBarandiaran, Myriam
dc.contributor.authorEstanga, Ainara
dc.contributor.authorLópez, Carolina
dc.contributor.authorAltuna Azkargorta, Miren
dc.contributor.authorIriondo, Ane
dc.contributor.authorSaldias, Jon
dc.contributor.authorGarcía-Sebastián, Maite
dc.contributor.authorCañada, Marta
dc.contributor.authorArriba, Maria de
dc.contributor.authorReparaz Escudero, Imanol
dc.contributor.authorLópez Sáez de Asteasu, Mikel
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.authorBalluerka, Nekane
dc.contributor.authorGorostiaga, Arantxa
dc.contributor.authorRos, Naia
dc.contributor.authorSoroa, Goretti
dc.contributor.authorDomper, Jara
dc.contributor.authorGayoso, Lucía
dc.contributor.authorArrizabalaga-López, María
dc.contributor.authorEtxeberria, Usune
dc.contributor.authorTorres, María Inés
dc.contributor.authorAlberdi, Elena
dc.contributor.authorCapetillo-Zarate, Estibaliz
dc.contributor.authorMateo-Abad, Maider
dc.contributor.authorVergara, Itziar
dc.contributor.authorMar, Javier
dc.contributor.authorMartínez-Lage, Pablo
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2025-07-04T09:31:35Z
dc.date.available2025-07-04T09:31:35Z
dc.date.issued2025-06-16
dc.date.updated2025-07-04T09:24:11Z
dc.description.abstractIntroduction: Growing research suggests that dementia is a complex disorder with multiple risk factors and causes. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated that lifestyle interventions could confer cognitive benefits. Inspired by this, the GOIZ-ZAINDU (GZ) feasibility study adapted the FINGER approach to the Basque context. Building upon the GZ study, the CITA GO-ON trial aims to enhance and expand the evidence supporting dementia prevention through a multidomain intervention of risk factor management and resilience promotion. Methods: It is a two-year, population-based, randomized controlled trial to prevent cognitive decline in adults aged 60–85 years with Cardiovascular Risk Factors, Aging and Dementia (CAIDE) risk score ≥6, no dementia, and belowthan- expected performance on at least one of three cognitive screening tests. Participants are randomized (1:1) to receive either Regular Health Advice (RHA) or a Multidomain Intervention (MD-Int) that encompasses cognitive training, socio-emotional skills, multicomponent physical exercise, nutritional and culinary intervention, and monitoring for cardiovascular risks, pharmacological drug mismanagement, and comorbidities. The primary outcome is the efficacy of the intervention to reduce the risk of cognitive decline measured by the global composite z-score of the modified Neuropsychological Test Battery over two years. The secondary outcomes measure cost-effectiveness, quality of life, and functional abilities. Blood samples and brain imaging will also be collected to evaluate the effects of the intervention on brain structure and plasma biomarkers. Results: Recruitment has been completed with 1051 participants selected (mean age (standard deviation, SD) of 69.65 (6.36), 58,50 % female, and mean CAIDE (SD) of 7.62 (1.427). The final participant is expected to complete the last study visit by the autumn of 2026. Discussion: The CITA GO-ON Study, as a part of the World-Wide FINGERS network, is designed to validate the efficacy of a multidomain lifestyle intervention for dementia prevention and contribute valuable data to inform public health strategies fostering healthy, active aging.en
dc.description.sponsorshipThe author(s) declare that financial support was received for the research and/or publication of this article. The main promotor of this project is CITA-alzhéimer Foundation. This work was partially funded by grant PLEC2021-008171 funded by MICIN/AEI/10.13039/501100011033 and by the European Union NextGenerationEU/PTR and supported by the Department of Health of the Basque Gobernment and Fundación hna (fundacionhna.es). It was also partially supported by a grant from the Basque Government (ref. IT1493-22), and by the Etorkizuna Eraikiz Initiative, promoted by the Gipuzkoa Provincial Council (grant number DGE20/02). This research is part of the Worldwide FINGERS Network, and we acknowledge the WW-FINGERS Network and its Global Scientific Coordinating Center for their contribution. The CITA GO-ON study is also part of the EU-FINGERS consortium, a Project funded by the Joint Program of Neurodegenerative Disorders project (EU-FINGERS: multimodal precision prevention toolbox for dementia in Alzheimer¿s disease) through the following funding organizations under the aegis of JPND.
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dc.identifier.citationTainta, M., Ecay-Torres, M., Barandiaran, M., Estanga, A., López, C., Altuna, M., Iriondo, A., Saldias, J., Garcia-Sebastian, M., Cañada, M., Arriba, M. de, Reparaz-Escudero, I., Sáez de Asteasu, M. L., Izquierdo, M., Balluerka, N., Gorostiaga, A., Ros, N., Soroa, G., Domper, J., Gayoso, L., Arrizabalaga-Lopez, M., Etxeberria, U., Torres, M. I., Alberdi, E., Capetillo-Zarate, E., Mateo-Abad, M., Vergara, I., Mar, J., Martinez-Lage, P. (2025). CITA GO-ON study: a community based multidomain lifestyle intervention to prevent cognitive decline: protocol design and recruitment process. Frontiers in Aging Neuroscience, 17, 1-16. https://doi.org/10.3389/fnagi.2025.1539711.
dc.identifier.doi10.3389/fnagi.2025.1539711
dc.identifier.issn1663-4365
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/54393
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.ispartofFrontiers in Aging Neuroscience (2025), vol. 17
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PLEC2021-008171/ES/
dc.relation.publisherversionhttps://doi.org/10.3389/fnagi.2025.1539711
dc.rights© 2025 Tainta, Ecay-Torres, Barandiaran, Estanga, López, Altuna, Iriondo, Saldias, Garcia-Sebastian, Cañada, de Arriba, Reparaz-Escudero, Sáez de Asteasu, Izquierdo, Balluerka, Gorostiaga, Ros, Soroa, Domper, Gayoso, Arrizabalaga-Lopez, Etxeberria, Torres, Alberdi, Capetillo-Zarate, Mateo-Abad, Vergara, Mar and Martinez-Lage. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCognitive impairmenten
dc.subjectDementia preventionen
dc.subjectLifestyleen
dc.subjectMultidomain interventionen
dc.subjectRandomized trial data collectionen
dc.titleCITA GO-ON study: a community based multidomain lifestyle intervention to prevent cognitive decline: protocol design and recruitment processen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicatione68a90dc-63ba-4efe-9d57-15b7ca2f4b54
relation.isAuthorOfPublicationda4f9064-c50c-4c86-9d80-f0a088a62517
relation.isAuthorOfPublicationef73585d-4750-4f56-9d4f-0d759232dbca
relation.isAuthorOfPublication.latestForDiscoverye68a90dc-63ba-4efe-9d57-15b7ca2f4b54

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