Neuromotor dysfunction as a major outcome domain of psychotic disorders: a 21-year follow-up study

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dc.contributor.authorPeralta Martín, Víctor
dc.contributor.authorGarcía de Jalón, Elena
dc.contributor.authorMoreno-Izco, Lucía
dc.contributor.authorPeralta, David
dc.contributor.authorJanda-Galán, Lucía
dc.contributor.authorSánchez Torres, Ana María
dc.contributor.authorCuesta, Manuel J.
dc.contributor.authorSEGPEPs Group
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua
dc.date.accessioned2025-08-14T11:43:04Z
dc.date.available2025-08-14T11:43:04Z
dc.date.issued2025-01-01
dc.date.updated2025-08-14T11:36:49Z
dc.description.abstractBackground The long-term stability of neuromotor domains assessed at the first episode of psychosis (FEP) and their ability for predicting a number of outcomes remains largely unknown, and this study addressed these issues. Methods This was a longitudinal study of 243 participants with FEP who were assessed at baseline for background variables and parkinsonism, dyskinesia, neurological soft signs (NSS) and catatonia, and reassessed 21 years later for the same neuromotor variables, psychopathology, functioning, personal recovery, cognitive performance and medical comorbidity. Stability of neuromotor ratings was assessed using the intraclass correlations coefficient and associations between the predictors and outcomes were examined using univariate and multivariate statistics. Results Baseline dyskinesia and NSS ratings showed excellent stability over time whereas that for parkinsonism and catatonia was relatively low. Neuromotor dysfunction at follow-up was independently predicted by a family history of schizophrenia, obstetric complications, neurodevelopmental delay, low premorbid IQ and baseline ratings of dyskinesia and NSS. Moreover, baseline dyskinesia and NSS ratings independently predicted more positive and negative symptoms, poor functioning and less personal recovery; catatonia predicted less personal recovery and more medical comorbidity. Baseline neuromotor ratings explained between 4% (for medical comorbidity) and 34% (for neuromotor dysfunction) of the variance in the outcomes. Lastly, neuromotor dysfunction at baseline highly predicted clinical staging at follow-up. Conclusion Baseline neuromotor domains show variable stability over time and relate distinctively to very long-term outcomes. Both baseline dyskinesia and NSS are trait markers of the disease process and robust predictors of the outcomes.en
dc.description.sponsorshipThe study was funded by the Spanish Ministry of Economy, Industry and Competitiveness (grant PI16/02148 and 19/01698) and the Regional Government of Navarra (grant 31/17 and 41/18).
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dc.format.mimetypeapplication/msword
dc.identifier.citationPeralta, V., García de Jalón, E., Moreno-Izco, L., Peralta, D., Janda, L., Sánchez-Torres, A. M., Cuesta, M. J., SEGPEPs Group (2024). Neuromotor dysfunction as a major outcome domain of psychotic disorders: a 21-year follow-up study. Schizophrenia Research, 263, 229-236. https://doi.org/10.1016/j.schres.2022.05.026.
dc.identifier.doi10.1016/j.schres.2022.05.026
dc.identifier.issn0920-9964
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/54743
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofSchizophrenia Research (2024), vol. 263
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI16%2F02148/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI19%2F01698/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//31%2F17/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//41%2F18/
dc.relation.publisherversionhttps://doi.org/10.1016/j.schres.2022.05.026
dc.rights© 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectParkinsonismen
dc.subjectDyskinesiaen
dc.subjectNeurological signsen
dc.subjectCatatonia, outcome, psychosisen
dc.titleNeuromotor dysfunction as a major outcome domain of psychotic disorders: a 21-year follow-up studyen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication6cfdb372-fb89-4760-b1b8-404b0f0ae941
relation.isAuthorOfPublication.latestForDiscovery6cfdb372-fb89-4760-b1b8-404b0f0ae941

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