Self-assembling protein nanoparticles in the design of vaccines: 2022 update

Morales Hernández, Sergio; Ugidos Damboriena, Nerea; López Sagaseta, Jacinto

Publication:
Self-assembling protein nanoparticles in the design of vaccines: 2022 update

dc.contributor.author	Morales Hernández, Sergio
dc.contributor.author	Ugidos Damboriena, Nerea
dc.contributor.author	López Sagaseta, Jacinto
dc.contributor.department	Ciencias de la Salud	es_ES
dc.contributor.department	Osasun Zientziak	eu
dc.contributor.funder	Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa	es
dc.date.accessioned	2022-11-30T09:55:13Z
dc.date.available	2022-11-30T09:55:13Z
dc.date.issued	2022
dc.date.updated	2022-11-18T13:38:08Z
dc.description.abstract	Vaccines constitute a pillar in the prevention of infectious diseases. The unprecedented emergence of novel immunization strategies due to the COVID-19 pandemic has again positioned vaccination as a pivotal measure to protect humankind and reduce the clinical impact and socioeconomic burden worldwide. Vaccination pursues the ultimate goal of eliciting a protective response in immunized individuals. To achieve this, immunogens must be efficiently delivered to prime the immune system and produce robust protection. Given their safety, immunogenicity, and flexibility to display varied and native epitopes, self-assembling protein nanoparticles represent one of the most promising immunogen delivery platforms. Currently marketed vaccines against the human papillomavirus, for instance, illustrate the potential of these nanoassemblies. This review is intended to provide novelties, since 2015, on the ground of vaccine design and self-assembling protein nanoparticles, as well as a comparison with the current emergence of mRNA-based vaccines. © 2022 by the authors.	en
dc.description.sponsorship	Jacinto López Sagaseta is a Ramón y Cajal Investigator, grant RYC-2017-21683, Ministry of Science and Innnovation of Spain. Nerea Ugidos-Damboriena is a recipient of a María Zambrano contract funded by UPNA and the Ministry of Universities of Spain within the Plan of Recovery, Transformation and Resilience and the European Recovery Instrument Next Generation EU.	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Morales-Hernández, S., Ugidos-Damboriena, N., & López-Sagaseta, J. (2022). Self-assembling protein nanoparticles in the design of vaccines: 2022 update. Vaccines, 10(9), 1447.	en
dc.identifier.doi	10.3390/vaccines10091447
dc.identifier.issn	2076-393X
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/44439
dc.language.iso	eng	en
dc.publisher	MDPI	en
dc.relation.ispartof	Vaccines 2022, 10, 1447	en
dc.relation.publisherversion	https://doi.org/10.3390/vaccines10091447
dc.rights	© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.	en
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject	Antibodies	en
dc.subject	Antigen	en
dc.subject	Foot and mouth disease (HFMD)	en
dc.subject	Hand	en
dc.subject	Human papillomavirus (HPV)	en
dc.subject	Immunogen	en
dc.subject	Nanoparticles	en
dc.subject	Norovirus (NoV)	en
dc.subject	SAPNs	en
dc.subject	Self-assembling protein nanoparticles	en
dc.subject	Vaccine	en
dc.subject	Virus	en
dc.subject	Virus-like particles	en
dc.subject	VLPs	en
dc.title	Self-assembling protein nanoparticles in the design of vaccines: 2022 update	en
dc.type	info:eu-repo/semantics/article
dc.type.version	Versión publicada / Argitaratu den bertsioa	es
dc.type.version	info:eu-repo/semantics/publishedVersion	en
dspace.entity.type	Publication