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Clinical, histopathologic and genetic features of rhabdoid meningiomas

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dc.contributor.authorGarrido Ruiz, Patricia Alejandraes_ES
dc.contributor.authorGonzález-Tablas, Maríaes_ES
dc.contributor.authorPasco Peña, Alejandroes_ES
dc.contributor.authorZelaya Huerta, María Victoria
dc.contributor.authorOrtiz, Javieres_ES
dc.contributor.authorOtero, Álvaroes_ES
dc.contributor.authorCorchete, Luis Antonioes_ES
dc.contributor.authorLudeña, María Doloreses_ES
dc.contributor.authorCaballero Martínez, María Cristinaes_ES
dc.contributor.authorCórdoba Iturriagagoitia, Aliciaes_ES
dc.contributor.authorFernández, Inmaculada Catalinaes_ES
dc.contributor.authorGonzález-Carreró Fojón, Joaquínes_ES
dc.contributor.authorHernández Laín, Aurelioes_ES
dc.contributor.authorOrfao, Albertoes_ES
dc.contributor.authorTabernero, María Doloreses_ES
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2023-05-05T11:23:48Z
dc.date.available2023-05-05T11:23:48Z
dc.date.issued2023
dc.date.updated2023-05-05T11:14:20Z
dc.description.abstractRhabdoid meningiomas (RM) shows heterogeneous histological findings, and a wide variety of chromosomal copy number alterations (CNA) are associated with an unpredictable course of the disease. In this study, we analyzed a series of 305 RM samples from patients previously reported in the literature and 33 samples from 23 patients studied in our laboratory. Monosomy 22-involving the minimal but most common recurrent region loss of the 22q11.23 chromosomal region was the most observed chromosomal alteration, followed by losses of chromosomes 14, 1, 6, and 19, polysomies of chromosomes 17, 1q, and 20, and gains of 13q14.2, 10p13, and 21q21.2 chromosomal regions. Based on their CNA profile, RM could be classified into two genetic subgroups with distinct clinicopathologic features characterized by the presence of (1) chromosomal losses only and (2) combined losses and gains of several chromosomes. The latter displays a higher frequency of WHO grade 3 tumors and poorer clinical outcomes.en
dc.description.sponsorshipThis research was funded by Consejería de Sanidad JCYL, Gerencia Regional de Salud, Spain grant numbers GRS 2132/A/20 and GRS 2315/A/21 and Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Madrid, Spain grant number CIBERONC CB16/12/00400.en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.identifier.citationGarrido Ruiz, P. A., González-Tablas, M., Pasco Peña, A., Zelaya Huerta, M. V., Ortiz, J., Otero, Á., Corchete, L. A., Ludeña, M. D., Caballero Martínez, M. C., Córdoba Iturriagagoitia, A., Fernández, I. C., González-Carreró Fojón, J., Hernández Laín, A., Orfao, A., & Tabernero, M. D. (2023). Clinical, histopathologic and genetic features of rhabdoid meningiomas. International Journal of Molecular Sciences, 24(2), 1116. https://doi.org/10.3390/ijms24021116en
dc.identifier.doi10.3390/ijms24021116
dc.identifier.issn1661-6596
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/45244
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofInternational Journal of Molecular Sciences, 2023, 24, 1116en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//CB16%2F12%2F00400/ES/en
dc.relation.publisherversionhttps://doi.org/10.3390/ijms24021116
dc.rights© 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectChromosome copy number alterationsen
dc.subjectDiagnosisen
dc.subjectHistopathologyen
dc.subjectPrognosisen
dc.subjectRhabdoid meningiomaen
dc.subjectSurvivalen
dc.titleClinical, histopathologic and genetic features of rhabdoid meningiomasen
dc.typeArtículo / Artikuluaes
dc.typeinfo:eu-repo/semantics/articleen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoveryfc740a9f-a1f1-46c3-bc2d-664eccdb4feb

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