Dose-response relationship between exercise duration and enhanced function and cognition in acutely hospitalized older adults: a secondary analysis of a randomized clinical Trial

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dc.contributor.authorLópez Sáez de Asteasu, Mikel
dc.contributor.authorMartínez Velilla, Nicolás
dc.contributor.authorZambom Ferraresi, Fabrício
dc.contributor.authorGalbete Jiménez, Arkaitz
dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.authorLusa Cadore, Eduardo
dc.contributor.authorAbizanda, Pedro
dc.contributor.authorGómez-Pavón, Javier
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentEstadística, Informática y Matemáticases_ES
dc.contributor.departmentEstatistika, Informatika eta Matematikaeu
dc.contributor.departmentInstitute of Smart Cities - ISCen
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua
dc.date.accessioned2024-11-06T11:09:58Z
dc.date.available2024-11-06T11:09:58Z
dc.date.issued2024-06-01
dc.date.updated2024-11-06T11:01:17Z
dc.description.abstractBackground and objectives: exercise may reverse functional decline in hospitalized older adults, but the optimal duration is unclear. This study examined the potential relationship between in-hospital multicomponent exercise program duration and changes in physical function, cognition, and muscle function to maximize exercise-related health benefits in acutely hospitalized older patients. Research design and methods: this secondary analysis of a multicenter randomized controlled trial examined the relationship between the duration of an in-hospital multicomponent exercise program and changes in physical function, cognition, and muscle strength in 570 acutely hospitalized older adults. Participants completed 3, 4, or 5-7 consecutive days of exercise based on the progression of their acute medical illness. The acute clinical condition of the older patients was similar across the study groups (i.e., 3/4/5-7 days) at admission. Outcomes included the Short Physical Performance Battery (SPPB) for functional capacity, Gait Velocity Test for gait speed, handgrip for muscle strength, and cognitive tests. Results: of the 570 patients included in the analysis, 298 were women (52.3%), and the mean (SD) age was 87.3 (4.8) years. Exercise groups increased SPPB scores compared with controls, with gains of 1.09 points after three days, 1.97 points after four days, and 2.02 points after 5-7 days (p < .001). The 4-day program showed the most significant benefit for functional capacity. Gait velocity increased by 0.11 m/s after 4 and 5-7 days (p = .032). Similar dose-response relationships were seen for handgrip strength and cognition, with 5-7 days showing more significant gains than three days (p < .05). Discussion and implications: multicomponent exercise programs enhance physical and cognitive function in hospitalized older adults, regardless of exercise dosage. A 4-day program significantly boosts functional capacity, although 5-7 days improves handgrip strength and cognition, highlighting the importance of exercise dosage in countering functional decline. Implementing evidence-based inpatient exercise prescriptions can help reverse muscle weakness and improve cognitive and physical function.en
dc.description.sponsorshipThis study was funded by a Gobierno de Navarra project Resolución grant 2186/2014 and acknowledged with the 'Beca Ortiz de Landazuri' for the best research clinical project in 2014. This study was also funded by a research grant PI17/01814 from the Ministerio de Economía, Industria y Competitividad (ISCIII, FEDER). N.M.-V. received funding from the 'la Caixa' Foundation (ID 100010434) under LCF/PR/PR15/51100006 agreement.
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSáez De Asteasu, M. L., Martínez-Velilla, N., Zambom-Ferraresi, F., Galbete, A., Ramírez-Vélez, R., Cadore, E. L., Abizanda, P., Gómez-Pavón, J., Izquierdo, M. (2024). Dose-response relationship between exercise duration and enhanced function and cognition in acutely hospitalized older adults: a secondary analysis of a randomized clinical Trial. Innovation in Aging, 8(6), 1-10. https://doi.org/10.1093/geroni/igae053.
dc.identifier.doi10.1093/geroni/igae053
dc.identifier.issn2399-5300
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/52457
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofInnovation in Aging (2024), vol. 8, núm. 6
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01814/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//2186%2F2014/
dc.relation.publisherversionhttps://doi.org/10.1093/geroni/igae053
dc.rights© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHospitalizationen
dc.subjectMulticomponent trainingen
dc.subjectVIVIFRAILen
dc.titleDose-response relationship between exercise duration and enhanced function and cognition in acutely hospitalized older adults: a secondary analysis of a randomized clinical Trialen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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