Physical activity is related to lower levels of neurofilament light and plasma tau protein: a 22-year follow-up study from adolescence to adulthood

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dc.contributor.authorEzzatvar, Yasmin
dc.contributor.authorLópez Gil, José Francisco
dc.contributor.authorYáñez-Sepúlveda, Rodrigo
dc.contributor.authorOlivares-Arancibia, Jorge
dc.contributor.authorPáez-Herrera, Jacqueline
dc.contributor.authorGarcía Hermoso, Antonio
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2025-07-02T08:11:48Z
dc.date.issued2025-06-01
dc.date.updated2025-07-02T08:05:30Z
dc.description.abstractPurpose: To investigate the association between physical activity (PA) and neurodegeneration biomarkers from adolescence to adulthood by examining tau protein and neurofilament light chain (NfL) levels in blood samples. Methods: The study analyzed data from adolescents aged 12–19 years who participated in Waves I (1994–1996) and V (2016–2018) of the Add Health study over a span of 22 years. It assessed PA through self-reported questionnaires. Neurodegeneration measures at Wave V used venous blood collected via phlebotomy. Samples were analyzed using single-molecule array (Simoa) technology on a Quanterix HD-1 analyzer, using digital enzyme-linked immunosorbent assay to quantify NfL and tau proteins from serum and plasma samples. Results: In the present study, 3,182 individuals participated, with females comprising 61% of the sample. Participants adhering to the PA guidelines in both waves reported lower levels of NfL (−0.583 pg/mL, 95% bias-corrected and accelerated (BCa) confidence interval (CI): −1.235 to −0.068) and tau protein levels (−0.244 pg/mL, 95% BCa CI: −0.405 to −0.078). Adjusted analyses confirmed significant lower levels of tau protein (−0.210 pg/mL, 95% BCa CI: −0.350 to −0.072) for Wave I adherents and even lower levels in NfL (−0.421 pg/mL, 95% BCa CI: −0.929 to −0.007) and tau protein levels (−0.229 pg/mL, 95% BCa CI: −0.412 to −0.053) for active participants in both waves. Discussion: Our findings suggest that consistent engagement in PA may reduce certain neurodegenerative biomarkers, potentially influencing neurological health outcomes.en
dc.description.sponsorshipThis research received no external funding and uses data from Add Health, a program project directed by Kathleen Mullan Harris and designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris at the University of North Carolina at Chapel Hill.
dc.embargo.lift2026-06-01
dc.embargo.terms2026-06-01
dc.format.mimetypeapplication/pdf
dc.identifier.citationEzzatvar, Y., López-Gil, J. F., Yáñez-Sepúlveda, R., Olivares-Arancibia, J., Páez-Herrera, J., García-Hermoso, A. (2025). Physical activity is related to lower levels of neurofilament light and plasma tau protein: a 22-year follow-up study from adolescence to adulthood. Journal of Adolescent Health, 76(6), 1055-1061. https://doi.org/10.1016/j.jadohealth.2025.02.003
dc.identifier.doi10.1016/j.jadohealth.2025.02.003
dc.identifier.issn1054-139X
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/54367
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofJournal of Adolescent Health (2025), vol. 76, núm. 6
dc.relation.publisherversionhttps://doi.org/10.1016/j.jadohealth.2025.02.003
dc.rights© 2025 Society for Adolescent Health and Medicine. This manuscript version is made available under the CC-BY-NC-ND 4.0
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectExerciseen
dc.subjectNeurofilament lighten
dc.subjectProspective designen
dc.subjectTau proteinen
dc.titlePhysical activity is related to lower levels of neurofilament light and plasma tau protein: a 22-year follow-up study from adolescence to adulthooden
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationa8a724dc-bd51-4ab2-8e46-97e362d3ba8f
relation.isAuthorOfPublicatione84ae68a-fa4a-4e00-be27-bedfffc8612e
relation.isAuthorOfPublication.latestForDiscoverye84ae68a-fa4a-4e00-be27-bedfffc8612e

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