Publication:
Health-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort study

dc.contributor.authorLópez-Herreros, J.
dc.contributor.authorMartínez González, Miguel Ángel
dc.contributor.authorGea, A.
dc.contributor.authorSánchez Villegas, María Almudena
dc.contributor.authorDierssen Sotos, Trinidad
dc.contributor.authorJiménez-Moleón, J. J.
dc.contributor.authorRuiz Canela, Miguel
dc.contributor.authorToledo, Estefanía
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.date.accessioned2023-10-23T15:19:42Z
dc.date.available2023-10-23T15:19:42Z
dc.date.issued2023
dc.date.updated2023-10-23T14:40:29Z
dc.description.abstractObjective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36) twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet). Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36–0.90], ptrend < 0.001; HRper+10points: 0.64 [95%CI, 0.54–0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46–0.97], ptrend = 0.025; HRper+10points: 0.86 [95%CI, 0.74–0.99]) were inversely associated with mortality in the model with repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these associations. Conclusions: Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous comorbidities or adherence to the MedDiet.en
dc.description.sponsorshipThis project was made possible by funding from the Spanish Government-Instituto de Salud Carlos III, and the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI18/00631, PI20/00564 and G03/140), from the Government of Navarra (27/2011, 45/2011, 122/2014), from the National Plan on Drugs (2020/021) as well as from the University of Navarra.en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/msworden
dc.identifier.citationLópez-Herreros, J., Martínez-González, M. A., Gea, A., Sánchez-Villegas, A., Dierssen-Sotos, T., Jiménez-Moleón, J. J., Ruiz-Canela, M., & Toledo, E. (2023). Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort study. Experimental Gerontology, 178, 112224. https://doi.org/10.1016/j.exger.2023.112224en
dc.identifier.doi10.1016/j.exger.2023.112224
dc.identifier.issn0531-5565
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/46611
dc.language.isoengen
dc.publisherElsevieren
dc.relation.ispartofExperimental Gerontology 178 (2023) 112224en
dc.relation.projectIDnfo:eu-repo/grantAgreement///PI10%2F02658en
dc.relation.projectIDnfo:eu-repo/grantAgreement///PI10%2F02293en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI13%2F00615/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI14%2F01668/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI14%2F01798/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI14%2F01764/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01795/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F00631/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00564/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//027%2F2011en
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//45%2F2011en
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//122%2F2014en
dc.relation.publisherversionhttps://doi.org/10.1016/j.exger.2023.112224
dc.rights© 2023 The Authors. This is an open access article under the CC BY-NC-ND license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCohorten
dc.subjectHealth-related quality of lifeen
dc.subjectMortalityen
dc.subjectSF-36en
dc.subjectSUN projecten
dc.titleHealth-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort studyen
dc.typeinfo:eu-repo/semantics/article
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
relation.isAuthorOfPublicationae8afd07-1f10-4da5-8582-93b90a18aa88
relation.isAuthorOfPublication.latestForDiscoveryae8afd07-1f10-4da5-8582-93b90a18aa88

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