Publication: Health-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort study
dc.contributor.author | López-Herreros, J. | |
dc.contributor.author | Martínez González, Miguel Ángel | |
dc.contributor.author | Gea, A. | |
dc.contributor.author | Sánchez Villegas, María Almudena | |
dc.contributor.author | Dierssen Sotos, Trinidad | |
dc.contributor.author | Jiménez-Moleón, J. J. | |
dc.contributor.author | Ruiz Canela, Miguel | |
dc.contributor.author | Toledo, Estefanía | |
dc.contributor.department | Institute on Innovation and Sustainable Development in Food Chain - ISFOOD | en |
dc.date.accessioned | 2023-10-23T15:19:42Z | |
dc.date.available | 2023-10-23T15:19:42Z | |
dc.date.issued | 2023 | |
dc.date.updated | 2023-10-23T14:40:29Z | |
dc.description.abstract | Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36) twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet). Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36–0.90], ptrend < 0.001; HRper+10points: 0.64 [95%CI, 0.54–0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46–0.97], ptrend = 0.025; HRper+10points: 0.86 [95%CI, 0.74–0.99]) were inversely associated with mortality in the model with repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these associations. Conclusions: Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous comorbidities or adherence to the MedDiet. | en |
dc.description.sponsorship | This project was made possible by funding from the Spanish Government-Instituto de Salud Carlos III, and the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI18/00631, PI20/00564 and G03/140), from the Government of Navarra (27/2011, 45/2011, 122/2014), from the National Plan on Drugs (2020/021) as well as from the University of Navarra. | en |
dc.format.mimetype | application/pdf | en |
dc.format.mimetype | application/msword | en |
dc.identifier.citation | López-Herreros, J., Martínez-González, M. A., Gea, A., Sánchez-Villegas, A., Dierssen-Sotos, T., Jiménez-Moleón, J. J., Ruiz-Canela, M., & Toledo, E. (2023). Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort study. Experimental Gerontology, 178, 112224. https://doi.org/10.1016/j.exger.2023.112224 | en |
dc.identifier.doi | 10.1016/j.exger.2023.112224 | |
dc.identifier.issn | 0531-5565 | |
dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/46611 | |
dc.language.iso | eng | en |
dc.publisher | Elsevier | en |
dc.relation.ispartof | Experimental Gerontology 178 (2023) 112224 | en |
dc.relation.projectID | nfo:eu-repo/grantAgreement///PI10%2F02658 | en |
dc.relation.projectID | nfo:eu-repo/grantAgreement///PI10%2F02293 | en |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI13%2F00615/ES/ | en |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F01668/ES/ | en |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F01798/ES/ | en |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F01764/ES/ | en |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01795/ES/ | en |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F00631/ES/ | en |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00564/ES/ | en |
dc.relation.projectID | info:eu-repo/grantAgreement/Gobierno de Navarra//027%2F2011 | en |
dc.relation.projectID | info:eu-repo/grantAgreement/Gobierno de Navarra//45%2F2011 | en |
dc.relation.projectID | info:eu-repo/grantAgreement/Gobierno de Navarra//122%2F2014 | en |
dc.relation.publisherversion | https://doi.org/10.1016/j.exger.2023.112224 | |
dc.rights | © 2023 The Authors. This is an open access article under the CC BY-NC-ND license. | en |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Cohort | en |
dc.subject | Health-related quality of life | en |
dc.subject | Mortality | en |
dc.subject | SF-36 | en |
dc.subject | SUN project | en |
dc.title | Health-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort study | en |
dc.type | info:eu-repo/semantics/article | |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | ae8afd07-1f10-4da5-8582-93b90a18aa88 | |
relation.isAuthorOfPublication.latestForDiscovery | ae8afd07-1f10-4da5-8582-93b90a18aa88 |
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