Health-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort study

López-Herreros, J.; Martínez González, Miguel Ángel; Gea, A.; Sánchez Villegas, María Almudena; Dierssen Sotos, Trinidad; Jiménez-Moleón, J. J.; Ruiz Canela, Miguel; Toledo, Estefanía

Publication:
Health-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort study

dc.contributor.author	López-Herreros, J.
dc.contributor.author	Martínez González, Miguel Ángel
dc.contributor.author	Gea, A.
dc.contributor.author	Sánchez Villegas, María Almudena
dc.contributor.author	Dierssen Sotos, Trinidad
dc.contributor.author	Jiménez-Moleón, J. J.
dc.contributor.author	Ruiz Canela, Miguel
dc.contributor.author	Toledo, Estefanía
dc.contributor.department	Institute on Innovation and Sustainable Development in Food Chain - ISFOOD	en
dc.date.accessioned	2023-10-23T15:19:42Z
dc.date.available	2023-10-23T15:19:42Z
dc.date.issued	2023
dc.date.updated	2023-10-23T14:40:29Z
dc.description.abstract	Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36) twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet). Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36–0.90], ptrend < 0.001; HRper+10points: 0.64 [95%CI, 0.54–0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46–0.97], ptrend = 0.025; HRper+10points: 0.86 [95%CI, 0.74–0.99]) were inversely associated with mortality in the model with repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these associations. Conclusions: Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous comorbidities or adherence to the MedDiet.	en
dc.description.sponsorship	This project was made possible by funding from the Spanish Government-Instituto de Salud Carlos III, and the European Regional Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI18/00631, PI20/00564 and G03/140), from the Government of Navarra (27/2011, 45/2011, 122/2014), from the National Plan on Drugs (2020/021) as well as from the University of Navarra.	en
dc.format.mimetype	application/pdf	en
dc.format.mimetype	application/msword	en
dc.identifier.citation	López-Herreros, J., Martínez-González, M. A., Gea, A., Sánchez-Villegas, A., Dierssen-Sotos, T., Jiménez-Moleón, J. J., Ruiz-Canela, M., & Toledo, E. (2023). Health-related quality of life and mortality in the ‘Seguimiento Universidad de Navarra’ prospective cohort study. Experimental Gerontology, 178, 112224. https://doi.org/10.1016/j.exger.2023.112224	en
dc.identifier.doi	10.1016/j.exger.2023.112224
dc.identifier.issn	0531-5565
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/46611
dc.language.iso	eng	en
dc.publisher	Elsevier	en
dc.relation.ispartof	Experimental Gerontology 178 (2023) 112224	en
dc.relation.projectID	nfo:eu-repo/grantAgreement///PI10%2F02658	en
dc.relation.projectID	nfo:eu-repo/grantAgreement///PI10%2F02293	en
dc.relation.projectID	info:eu-repo/grantAgreement/MINECO//PI13%2F00615/ES/	en
dc.relation.projectID	info:eu-repo/grantAgreement/MINECO//PI14%2F01668/ES/	en
dc.relation.projectID	info:eu-repo/grantAgreement/MINECO//PI14%2F01798/ES/	en
dc.relation.projectID	info:eu-repo/grantAgreement/MINECO//PI14%2F01764/ES/	en
dc.relation.projectID	info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01795/ES/	en
dc.relation.projectID	info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F00631/ES/	en
dc.relation.projectID	info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00564/ES/	en
dc.relation.projectID	info:eu-repo/grantAgreement/Gobierno de Navarra//027%2F2011	en
dc.relation.projectID	info:eu-repo/grantAgreement/Gobierno de Navarra//45%2F2011	en
dc.relation.projectID	info:eu-repo/grantAgreement/Gobierno de Navarra//122%2F2014	en
dc.relation.publisherversion	https://doi.org/10.1016/j.exger.2023.112224
dc.rights	© 2023 The Authors. This is an open access article under the CC BY-NC-ND license.	en
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject	Cohort	en
dc.subject	Health-related quality of life	en
dc.subject	Mortality	en
dc.subject	SF-36	en
dc.subject	SUN project	en
dc.title	Health-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort study	en
dc.type	info:eu-repo/semantics/article
dc.type.version	Versión publicada / Argitaratu den bertsioa	es
dc.type.version	info:eu-repo/semantics/publishedVersion	en
dspace.entity.type	Publication
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