Meta-analysis of prevalence of wheezing and recurrent wheezing in infants

Álvarez Álvarez, Ismael; Niu, Hao; Guillén Grima, Francisco; Aguinaga Ontoso, Inés

Publication:
Meta-analysis of prevalence of wheezing and recurrent wheezing in infants

dc.contributor.author	Álvarez Álvarez, Ismael
dc.contributor.author	Niu, Hao
dc.contributor.author	Guillén Grima, Francisco
dc.contributor.author	Aguinaga Ontoso, Inés
dc.contributor.department	Ciencias de la Salud	es_ES
dc.contributor.department	Osasun Zientziak	eu
dc.date.accessioned	2018-06-17T12:16:39Z
dc.date.available	2018-06-17T12:16:39Z
dc.date.issued	2016
dc.description.abstract	Background: Wheezing affects children’s quality of life, and is related with asthma in childhood. Although prevalence of wheezing has been previously studied in several countries, there are no reference of worldwide prevalence in infants. The aim of this meta-analysis is to estimate the prevalence of wheezing and recurrent wheezing in infants aged up to two years, and compare the prevalence across world regions. Methods: Literature search was conducted in MEDLINE and SCOPUS databases, looking for observational studies published up to June 2016, including as keywords “prevalence” or “epidemiology” combined with “wheeze”, “wheezing” or “asthma symptoms” and “infant” or “preschool”. Fast*Pro software and random effects Bayesian model were used. Heterogeneity was estimated using I2 statistic, and sensitivity analyses were performed. Results: We identified 109 studies after duplicates were removed. After exclusions, 14 studies were included in the meta-analysis. Prevalence of wheezing and recurrent wheezing were 36.06% (95% CI 35.17-36.96), and 17.41% (95% CI 16.74-18.09), respectively. In European countries, prevalence of wheezing was 30.68% (95% CI 28.97-32.45), and 12.35% (95% CI 11.27-13.47) for recurrent wheezing. Prevalence of wheezing and recurrent wheezing in Latin America were higher, 40.55% (95% CI 39.40-41.71), and 19.27% (95% CI 18.44-20.11), respectively. In Africa, prevalence of wheezing was 15.97% (95% CI 14.05-18.00). Low or no heterogeneity was found in all cases. Conclusions: More than one third of infants suffer from wheezing and almost one fifth from recurrent wheezing, being these illnesses especially prevalent in Latin American countries, pointing out an important public health problem.	en
dc.format.mimetype	application/pdf	en
dc.identifier.doi	10.1016/j.aller.2016.08.011
dc.identifier.issn	0301-0546 (Print)
dc.identifier.issn	1578-1267 (Electronic)
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/28894
dc.language.iso	eng	en
dc.publisher	Elsevier	en
dc.relation.ispartof	Allergologia et Immunopathologia, Volume 46, Issue 3, May–June 2018, Pages 210-217	en
dc.relation.publisherversion	https://doi.org/10.1016/j.aller.2016.08.011
dc.rights	© 2016 SEICAP. Published by Elsevier España, S.L.U. The manuscript version is made available under the CC BY-NC-ND 4.0 license.	en
dc.rights.accessRights	Acceso abierto / Sarbide irekia	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	en
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject	Epidemiology	en
dc.subject	Infants	en
dc.subject	Meta-analysis	en
dc.subject	Prevalence	en
dc.subject	Recurrent wheezing	en
dc.subject	Wheezing	en
dc.title	Meta-analysis of prevalence of wheezing and recurrent wheezing in infants	en
dc.type	info:eu-repo/semantics/article
dc.type.version	Versión aceptada / Onetsi den bertsioa	es
dc.type.version	info:eu-repo/semantics/acceptedVersion	en
dspace.entity.type	Publication
relation.isAuthorOfPublication	dfbf180f-dd66-42b9-ba45-2de0b3a334d5
relation.isAuthorOfPublication	e7178013-f5e6-4100-80b2-23f1d6cb6408
relation.isAuthorOfPublication.latestForDiscovery	dfbf180f-dd66-42b9-ba45-2de0b3a334d5

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