Comparison of 0.12% chlorhexidine and a new bone bioactive liquid, BBL, in mouthwash for oral wound healing: a randomized, double blind clinical human trial

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dc.contributor.authorFerrés‐Amat, Eduard
dc.contributor.authorAl Madhoun, Ashraf
dc.contributor.authorFerrés-Amat, Elvira
dc.contributor.authorCarrió, Neus
dc.contributor.authorBarajas Vélez, Miguel Ángel
dc.contributor.authorAl-Madhoun, Areej Said
dc.contributor.authorFerrés-Padró, Eduard
dc.contributor.authorMarti, Carles
dc.contributor.authorAtari, Maher
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa, OTRI project, reference number 2020907094es
dc.date.accessioned2023-04-24T17:33:10Z
dc.date.available2023-04-24T17:33:10Z
dc.date.issued2022
dc.date.updated2023-04-24T17:22:18Z
dc.description.abstractFollowing surgery, healing within the oral cavity occurs in a hostile environment, and proper oral care and hygiene are required to accelerate recovery. The aim of the current study is to investigate and compare the bioreactivity characteristics of mouthwashes based on either chlorhexidine (CHX) or a novel bone bioactive liquid (BBL) in terms of oral healing within seven days application post-surgery. A randomized, double blind clinical trial was conducted in 81 patients, wherein the mouthwashes were applied twice a day for a period of 7 days. The visual analog scale (VAS) protocol was applied to determine pain index scores. Early wound healing index (EHI) score was determined for evaluating oral cavity healing progress. No adverse effects were observed using the mouthwashes, but CHX application resulted in stained teeth. Applications of both CHX and BBL were sufficient to reduce pain over a period of 7 days. However, the BBL group demonstrated a statistically significant reduction in VAS scores starting on day 4. The EHI scores were significantly higher in the BBL group compared with the CHX group, independent of tooth location. No differences in either VAS or EHI scores due to gender were observed. Compared with the commercially available CHX mouthwash, application of the BBL mouthwash reduced pain and accelerated oral cavity healing to a greater extent, suggesting it effectively improves the oral cavity microenvironment at the wound site in mediating soft tissue regeneration.en
dc.description.sponsorshipThis study was funded by the OTRI project, reference number 2020907094, signed in May 2020 with the Public University of Navarra, Navarra, Spain.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationFerrés-Amat, E., Al Madhoun, A., Ferrés-Amat, E., Carrió, N., Barajas, M., Al-Madhoun, A. S., Ferrés-Padró, E., Marti, C., & Atari, M. (2022). Comparison of 0. 12% chlorhexidine and a new bone bioactive liquid, bbl, in mouthwash for oral wound healing: A randomized, double blind clinical human trial. Journal of Personalized Medicine, 12(10), 1725. https://doi.org/10.3390/jpm12101725en
dc.identifier.doi10.3390/jpm12101725
dc.identifier.issn2075-4426
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/45174
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofJournal of Personalized Medicine 2022, 12(10), 1725en
dc.relation.publisherversionhttps://doi.org/10.3390/jpm12101725
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectChlorhexidineen
dc.subjectBone bioactive liquiden
dc.subjectBBLen
dc.subjectTheravexen
dc.subjectOral wound healingen
dc.subjectPain index scoreen
dc.subjectEarly wound healing index scoreen
dc.titleComparison of 0.12% chlorhexidine and a new bone bioactive liquid, BBL, in mouthwash for oral wound healing: a randomized, double blind clinical human trialen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication2e998efa-ca5a-491e-9e7f-a8fbbd0094ce
relation.isAuthorOfPublication.latestForDiscovery2e998efa-ca5a-491e-9e7f-a8fbbd0094ce

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