Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena

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dc.contributor.authorPetermann-Rocha, Fanny
dc.contributor.authorVillagrán, Marcelo
dc.contributor.authorTroncoso, Claudia
dc.contributor.authorMardones, Lorena
dc.contributor.authorLeiva, Ana María
dc.contributor.authorMartínez, María Adela
dc.contributor.authorGarrido-Méndez, Alex
dc.contributor.authorPoblete-Valderrama, Felipe
dc.contributor.authorSalas-Bravo, Carlos
dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.authorUlloa, Natalia
dc.contributor.authorPérez-Bravo, Francisco
dc.contributor.authorCelis Morales, Carlos
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2024-10-02T11:11:50Z
dc.date.available2024-10-02T11:11:50Z
dc.date.issued2018
dc.date.updated2024-10-02T11:01:54Z
dc.description.abstractBackground: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPetermann, F., Villagrán, M., Troncoso, C., Mardones, L., Leiva, A. M., Martínez, M. A., Garrido-Méndez, A., Poblete-Valderrama, F., Salas-Bravo, C., Ramírez-Vélez, R., Ulloa, N., Pérez-Bravo, F., Celis-Morales, C. (2018). Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena. Revista Medica de Chile, 146(6), 717-726. https://doi.org/10.4067/s0034-98872018000600717.
dc.identifier.doi10.4067/s0034-98872018000600717
dc.identifier.issn0034-9887
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/51940
dc.language.isospa
dc.publisherSociedad Médica de Santiago
dc.relation.ispartofRevista Medica de Chile (2018), vol. 146, núm. 6
dc.relation.publisherversionhttps://doi.org/10.4067/s0034-98872018000600717
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdiposityen
dc.subjectAlpha-ketoglutarate-dependent dioxygenase FTOen
dc.subjectGenotypeen
dc.subjectObesityen
dc.titleAsociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilenaes_ES
dc.title.alternativeAssociation between FTO (ns9939609) genotype and adiposity markers in Chilean adultsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationd0c2c11e-01d0-46ff-93b4-36b11beaf269
relation.isAuthorOfPublication.latestForDiscoveryd0c2c11e-01d0-46ff-93b4-36b11beaf269

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