Effect of a dietary intervention based on the mediterranean diet on the quality of life of patients recovered from depression: analysis of the PREDIDEP randomized trial

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dc.contributor.authorCabrera Suárez, Beatriz
dc.contributor.authorLahortiga Ramos, Francisca
dc.contributor.authorSayón-Orea, Carmen
dc.contributor.authorHernández-Fleta, José L.
dc.contributor.authorGonzález Pinto, Ana
dc.contributor.authorMolero, Patricio
dc.contributor.authorVega-Pérez, Rosario
dc.contributor.authorSánchez Villegas, María Almudena
dc.contributor.authorCabrera, Claudio
dc.contributor.authorPla, Jorge
dc.contributor.authorChiclana Actis, Carlos
dc.contributor.authorVega-Pérez, P.
dc.contributor.authorNavarro, S.
dc.contributor.authorOrtuño, Felipe
dc.contributor.authorFlorido Rodríguez, Mónica
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.date.accessioned2023-06-27T08:13:17Z
dc.date.available2023-06-27T08:13:17Z
dc.date.issued2023
dc.date.updated2023-06-27T07:58:25Z
dc.description.abstractIntroduction: There is substantial evidence supporting that improving diet quality leads to improved healthrelated quality of life (HRQoL). Our major aim was to assess the effectiveness of a Mediterranean diet–based nutritional intervention to improve HRQoL in the context of a secondary prevention trial of depression. Secondarily to assess its effectiveness among adults aged 60 or more years. Methods: The PREDIDEP study is a 2-year multicentre, randomized, single-blinded nutritional trial. At baseline and at 1-year and 2-year follow-up, SF-36 health survey questionnaire was collected to evaluate participants' HRQoL (total and specific range for each of the 8 dimensions: 0 to 100 points). Mixed effect linear models were used to assess changes in HRQoL according to adherence to the Mediterranean diet. The trial was registered at ClinicalTrials.gov NCT03081065. Results: After 2 years of intervention, the Mediterranean Diet intervention group compared to control group (without nutritional intervention, only usual clinical care) showed an improvement in some dimensions of HRQoL such as Mental Health (7.22; 95 % CI = 2.22–12.22) (between-group difference: 6.79; 95 % CI − 0.14–13.73, p = 0.055); Vitality (9.51; 95 % CI = 4.00–15.03) (between-group difference: 9.00; 95 % CI 1.75–16.25, p = 0.020); Mental Summary Component (2.83; 95 % CI = 0.55–5.11) (between-group difference: 1.17; 95 % CI = − 1.96–4.30, p = 0.462); and General Health (10.70; 95 % CI = 5.58–15.81) (between-group difference: 6.20; 95 % CI = − 0.89–13.28, p = 0.086). Similar results were observed for participants aged 60 or more years. Conclusion: The intervention based on Mediterranean diet in patients with previous depression seems to be effective in improving HRQoL, especially the mental dimensions. This effect is also observed among participants aged 60 or more years.en
dc.description.sponsorshipThis study was externally funded by the Spanish Ministry of Science and Innovation (Carlos III National Health Institute-ISCIII), PI16/01274.en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/msworden
dc.identifier.citationCabrera-Suárez, B. M., Lahortiga-Ramos, F., Sayon-Orea, C., Hernández-Fleta, J. L., González-Pinto, A., Molero, P., Vega-Pérez, R., Sánchez-Villegas, A., Cabrera, C., Pla, J., Chiclana-Actis, C., Vega-Pérez, P., Navarro, S., Ortuño, F., & Florido, M. (2023). Effect of a dietary intervention based on the Mediterranean diet on the quality of life of patients recovered from depression: Analysis of the PREDIDEP randomized trial. Experimental Gerontology, 175, 112149. https://doi.org/10.1016/j.exger.2023.112149en
dc.identifier.doi10.1016/j.exger.2023.112149
dc.identifier.issn0531-5565
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/45612
dc.language.isoengen
dc.publisherElsevieren
dc.relation.ispartofExperimental Gerontology, 175 (2023) 112149en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI16%2F01274/ES/
dc.relation.publisherversionhttps://doi.org/10.1016/j.exger.2023.112149
dc.rights© 2023 The Authors. This is an open access article under the CC BY-NC-ND license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectClinical trialen
dc.subjectDepressionen
dc.subjectMediterranean dieten
dc.subjectOlive oilen
dc.subjectQuality of lifeen
dc.titleEffect of a dietary intervention based on the mediterranean diet on the quality of life of patients recovered from depression: analysis of the PREDIDEP randomized trialen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationae8afd07-1f10-4da5-8582-93b90a18aa88
relation.isAuthorOfPublication.latestForDiscoveryae8afd07-1f10-4da5-8582-93b90a18aa88

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