Plasma inflammatory biomarkers and anorexia of ageing among community-dwelling older adults: an exploratory analysis of the MAPT Study

Sánchez Sánchez, Juan Luis; Guyonnet, Sophie; Lucas, Alexandre; Parini, Angelo; Rolland, Y.; Souto Barreto, Philipe de

Plasma inflammatory biomarkers and anorexia of ageing among community-dwelling older adults: an exploratory analysis of the MAPT Study

dc.contributor.author	Sánchez Sánchez, Juan Luis
dc.contributor.author	Guyonnet, Sophie
dc.contributor.author	Lucas, Alexandre
dc.contributor.author	Parini, Angelo
dc.contributor.author	Rolland, Y.
dc.contributor.author	Souto Barreto, Philipe de
dc.contributor.department	Ciencias de la Salud	es_ES
dc.contributor.department	Osasun Zientziak	eu
dc.date.accessioned	2024-05-08T15:19:32Z
dc.date.available	2024-05-08T15:19:32Z
dc.date.issued	2023
dc.date.updated	2024-05-08T14:54:08Z
dc.description.abstract	Anorexia of aging and biological aging might share physiological underpinnings. The aim of this secondary analysis was to investigate the associations between circulating inflammation-related markers and anorexia of aging in community-dwelling older adults. C-reactive protein (CRP), tumor necrosis factor receptor-1 (TNFR-1), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and growth/differentiation factor-15 (GDF-15) were measured in plasma. Anorexia of aging was defined by the response “severe/moderate decrease in food intake” to the first item of the Mini-Nutritional Assessment. We included 463 subjects (median age=74y, IQR=71–78; 63.1% women). 33 subjects (7.1%) presented with anorexia at baseline, whereas 25 out of 363 (6.9%) developed it along 1-year follow-up. We found that TNFR1 (OR=1.74, 95%CI=1.27–2.39) and GDF-15 (OR=1.38, 95%CI=1.01–1.89) were associated with a significant increase in the odds of presenting with anorexia of aging cross-sectionally. No further significant associations were found. Biological aging mechanisms might be involved in the pathogenesis of anorexia of aging.	en
dc.format.mimetype	application/pdf	en
dc.format.mimetype	application/msword	en
dc.identifier.citation	Sánchez-Sánchez, J. L., Guyonnet, S., Lucas, A., Parini, A., Rolland, Y., & De Souto Barreto, P. (2023). Plasma inflammatory biomarkers and anorexia of ageing among community-dwelling older adults: An exploratory analysis of the mapt study. The Journal of Nutrition, Health and Aging, 27(11), 1127-1131. https://doi.org/10.1007/s12603-023-2024-8	en
dc.identifier.doi	10.1007/s12603-023-2024-8
dc.identifier.issn	1279-7707
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/48081
dc.language.iso	eng	en
dc.publisher	Springer	en
dc.relation.ispartof	The Journal of Nutrition, Health and Aging 27(11), 2023, 1127-1131	en
dc.relation.publisherversion	https://doi.org/10.1007/s12603-023-2024-8
dc.rights	© Serdi and Springer-Verlag International SAS, part of Springer Nature, 2023. CC BY-NC-ND 4.0 Attribution-NonCommercial-NoDerivs 4.0 International.	en
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject	Anorexia of aging	en
dc.subject	Biomarkers	en
dc.subject	Inflammation	en
dc.subject	Malnutrition	en
dc.title	Plasma inflammatory biomarkers and anorexia of ageing among community-dwelling older adults: an exploratory analysis of the MAPT Study	en
dc.type	info:eu-repo/semantics/article
dc.type.version	info:eu-repo/semantics/publishedVersion
dspace.entity.type	Publication
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