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Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults

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dc.contributor.authorCedeño Veloz, Bernardo Abel
dc.contributor.authorLozano Vicario, Lucía
dc.contributor.authorZambom Ferraresi, Fabrício
dc.contributor.authorFernández Irigoyen, Joaquín
dc.contributor.authorSantamaría Martínez, Enrique
dc.contributor.authorRodríguez-García, Alba
dc.contributor.authorRomero Ortuno, Román
dc.contributor.authorMondragón Rubio, Jaime
dc.contributor.authorRuiz-Ruiz, Javier
dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.authorMartínez Velilla, Nicolás
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoaes
dc.date.accessioned2023-11-14T19:06:47Z
dc.date.available2023-11-14T19:06:47Z
dc.date.issued2023
dc.date.updated2023-11-14T18:20:53Z
dc.description.abstractOsteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture risk, particularly in older adults. Thus, new technologies are necessary to improve the accuracy of fracture risk estimation. In this observational study, we aimed to explore the association between serum cytokines and hip fracture status in older adults, and their associations with fracture risk using the FRAX reference tool. We investigated the use of a proximity extension assay (PEA) with Olink. We compared the characteristics of the population, functional status and detailed body composition (determined using densitometry) between groups. We enrolled 40 participants, including 20 with hip fracture and 20 without fracture, and studied 46 cytokines in their serum. After conducting a score plot and two unpaired t-tests using the Benjamini-Hochberg method, we found that Interleukin 6 (IL-6), Lymphotoxin-alpha (LT-α), Fms-related tyrosine kinase 3 ligand (FLT3LG), Colony stimulating factor 1 (CSF1), and Chemokine (C-C motif) ligand 7 (CCL7) were significantly different between fracture and non-fracture patients (p < 0.05). IL-6 had a moderate correlation with FRAX (R2 = 0.409, p < 0.001), while CSF1 and CCL7 had weak correlations with FRAX. LT-α and FLT3LG exhibited a negative correlation with the risk of fracture. Our results suggest that targeted proteomic tools have the capability to identify differentially regulated proteins and may serve as potential markers for estimating fracture risk. However, longitudinal studies will be necessary to validate these results and determine the temporal patterns of changes in cytokine profiles.en
dc.description.sponsorshipOpen Access funding provided by Universidad Pública de Navarra. Funding for this project came from NM-V received funding from the “La Caixa” Foundation (ID 100010434), under agreement LCF/PR/PR15/51100006. ES also received funding from the grant from Department of Economic and Business Development from Government of Navarra (Ref. 0011-1411-2023-000028).en
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dc.format.mimetypeapplication/zipen
dc.identifier.citationCedeno-Veloz, B. A., Lozano-Vicario, L., Zambom-Ferraresi, F., Fernández-Irigoyen, J., Santamaría, E., Rodríguez-García, A., Romero-Ortuno, R., Mondragon-Rubio, J., Ruiz-Ruiz, J., Ramírez-Vélez, R., Izquierdo, M., Martínez-Velilla, N. (2023) Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults. Immunity & Ageing, 20(1), 1-11. https://doi.org/10.1186/s12979-023-00379-z.en
dc.identifier.doi10.1186/s12979-023-00379-z
dc.identifier.issn1742-4933
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/46774
dc.language.isoengen
dc.publisherBMCen
dc.relation.ispartofImmunity and Ageing 2023, 20(1), 55en
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//0011-1411-2023-000028en
dc.relation.publisherversionhttps://doi.org/10.1186/s12979-023-00379-z
dc.rights© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License.en
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCytokinesen
dc.subjectHip fracturesen
dc.subjectBiomarkersen
dc.subjectPrognosisen
dc.subjectFRAXen
dc.titleEffect of immunology biomarkers associated with hip fracture and fracture risk in older adultsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery3e6a0af4-f362-4385-99bb-e24e79a7a539

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