Clinical features and incidence trends of amyotrophic lateral sclerosis in Navarre, Spain, 2007-2018: a population-based study
| dc.contributor.author | Jericó Pascual, Ivonne | |
| dc.contributor.author | Elizalde Beiras, Itsaso | |
| dc.contributor.author | Pagola Lorz, María Inmaculada | |
| dc.contributor.author | Torné, Laura | |
| dc.contributor.author | Galbete Jiménez, Arkaitz | |
| dc.contributor.author | Delfrade Osinaga, J. | |
| dc.contributor.author | Vicente Cemborain, Esther | |
| dc.contributor.department | Osasun Zientziak | eu |
| dc.contributor.department | Institute of Smart Cities - ISC | en |
| dc.contributor.department | Ciencias de la Salud | es_ES |
| dc.date.accessioned | 2024-02-09T15:30:46Z | |
| dc.date.available | 2024-02-09T15:30:46Z | |
| dc.date.issued | 2021 | |
| dc.date.updated | 2024-02-09T10:53:06Z | |
| dc.description | Alojado según Res. CNEAI 5/12/23 (ANECA) | es_ES |
| dc.description.abstract | Objective: Amyotrophic Lateral Sclerosis (ALS) is a heterogeneous neurodegenerative disorder with a median survival of 3 years. The aim of our study is to analyze the incidence, age-related phenotype and clinical onset, geographical distribution, survival and diagnostic delay of ALS in Navarre. Methods: This is a population-based observational retrospective study, including all residents of Navarre (a northern Spanish region) from 2007 to 2018, who were followed until 30th September 2020. Results: We observed a global incidence 2.47/100,000 person-years, with an upward trend throughout the study, with the highest being in the age group of 70¿74 years old. Point prevalence in December 2018 was 6.64/100,000 inhabitants (95%CI: 4.52¿8.45). Upper limbs weakness onset was the most frequent in young people (<60 years), and bulbar, lower limbs weakness, generalized and respiratory associated with older age. Bulbar phenotype is the most frequent in women and in 80+ group. The median survival from clinical onset was 27.7 months (95%CI: 24.0¿31.4), higher in spinal phenotype and younger onset age, and the diagnosis delay was 10.0 months (95%CI: 8.9¿11.2) from clinical onset. Conclusions: We have observed a trend of increasing incidence in older people where the bulbar phenotype and female predominance. © 2021 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Jericó I., Elizalde-Beiras I., Pagola I., Torné L., Galbete A., Delfrade-Osinaga J., Vicente E. (2021) Clinical features and incidence trends of amyotrophic lateral sclerosis in Navarre, Spain, 2007¿2018: a population-based study. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 5-6, 401-409. https://doi.org/10.1080/21678421.2021.1891249. | en |
| dc.identifier.doi | 10.1080/21678421.2021.1891249 | es_ES |
| dc.identifier.issn | 2167-8421 | es_ES |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/47410 | |
| dc.language.iso | eng | en |
| dc.publisher | Taylor & Francis | en |
| dc.relation.ispartof | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 5-6, 401-409 | en |
| dc.relation.publisherversion | https://doi.org/10.1080/21678421.2021.1891249 | es_ES |
| dc.rights | * | es_ES |
| dc.rights.accessRights | info:eu-repo/semantics/closedAccess | |
| dc.title | Clinical features and incidence trends of amyotrophic lateral sclerosis in Navarre, Spain, 2007-2018: a population-based study | en |
| dc.type | info:eu-repo/semantics/article | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | de8262ba-1204-4fff-a6d9-4a1b252d2655 | |
| relation.isAuthorOfPublication | 4bb570ab-10a2-4b9a-8ee8-893bbd090df6 | |
| relation.isAuthorOfPublication | 9c5cc166-c8f5-478c-ab34-358ef48eb246 | |
| relation.isAuthorOfPublication | 13639375-c4c5-4d39-84df-ba61475a1391 | |
| relation.isAuthorOfPublication.latestForDiscovery | de8262ba-1204-4fff-a6d9-4a1b252d2655 |