Clinical features and incidence trends of amyotrophic lateral sclerosis in Navarre, Spain, 2007-2018: a population-based study

dc.contributor.authorJericó Pascual, Ivonne
dc.contributor.authorElizalde Beiras, Itsaso
dc.contributor.authorPagola Lorz, María Inmaculada
dc.contributor.authorTorné, Laura
dc.contributor.authorGalbete Jiménez, Arkaitz
dc.contributor.authorDelfrade Osinaga, J.
dc.contributor.authorVicente Cemborain, Esther
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentInstitute of Smart Cities - ISCen
dc.contributor.departmentCiencias de la Saludes_ES
dc.date.accessioned2024-02-09T15:30:46Z
dc.date.available2024-02-09T15:30:46Z
dc.date.issued2021
dc.date.updated2024-02-09T10:53:06Z
dc.descriptionAlojado según Res. CNEAI 5/12/23 (ANECA)es_ES
dc.description.abstractObjective: Amyotrophic Lateral Sclerosis (ALS) is a heterogeneous neurodegenerative disorder with a median survival of 3 years. The aim of our study is to analyze the incidence, age-related phenotype and clinical onset, geographical distribution, survival and diagnostic delay of ALS in Navarre. Methods: This is a population-based observational retrospective study, including all residents of Navarre (a northern Spanish region) from 2007 to 2018, who were followed until 30th September 2020. Results: We observed a global incidence 2.47/100,000 person-years, with an upward trend throughout the study, with the highest being in the age group of 70¿74 years old. Point prevalence in December 2018 was 6.64/100,000 inhabitants (95%CI: 4.52¿8.45). Upper limbs weakness onset was the most frequent in young people (<60 years), and bulbar, lower limbs weakness, generalized and respiratory associated with older age. Bulbar phenotype is the most frequent in women and in 80+ group. The median survival from clinical onset was 27.7 months (95%CI: 24.0¿31.4), higher in spinal phenotype and younger onset age, and the diagnosis delay was 10.0 months (95%CI: 8.9¿11.2) from clinical onset. Conclusions: We have observed a trend of increasing incidence in older people where the bulbar phenotype and female predominance. © 2021 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationJericó I., Elizalde-Beiras I., Pagola I., Torné L., Galbete A., Delfrade-Osinaga J., Vicente E. (2021) Clinical features and incidence trends of amyotrophic lateral sclerosis in Navarre, Spain, 2007¿2018: a population-based study. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 5-6, 401-409. https://doi.org/10.1080/21678421.2021.1891249.en
dc.identifier.doi10.1080/21678421.2021.1891249es_ES
dc.identifier.issn2167-8421es_ES
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/47410
dc.language.isoengen
dc.publisherTaylor & Francisen
dc.relation.ispartofAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 5-6, 401-409en
dc.relation.publisherversionhttps://doi.org/10.1080/21678421.2021.1891249es_ES
dc.rights*es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/closedAccess
dc.titleClinical features and incidence trends of amyotrophic lateral sclerosis in Navarre, Spain, 2007-2018: a population-based studyen
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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relation.isAuthorOfPublication9c5cc166-c8f5-478c-ab34-358ef48eb246
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relation.isAuthorOfPublication.latestForDiscoveryde8262ba-1204-4fff-a6d9-4a1b252d2655

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