Expansion of signal transduction pathways in fungi by extensive genome duplication

Corrochano, Luis M.; Kuo, Alan; Marcet Houben, Marina; Oguiza Tomé, José Antonio; Pisabarro de Lucas, Gerardo

Publication:
Expansion of signal transduction pathways in fungi by extensive genome duplication

dc.contributor.author	Corrochano, Luis M.
dc.contributor.author	Kuo, Alan
dc.contributor.author	Marcet Houben, Marina
dc.contributor.author	Oguiza Tomé, José Antonio
dc.contributor.author	Pisabarro de Lucas, Gerardo
dc.contributor.department	Producción Agraria	es_ES
dc.contributor.department	Nekazaritza Ekoizpena	eu
dc.date.accessioned	2020-09-22T07:53:15Z
dc.date.available	2020-09-22T07:53:15Z
dc.date.issued	2016
dc.description.abstract	Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of P. blakesleeanus and M. circinelloides and show that they have been shaped by an extensive genome duplication or, most likely, a whole-genome duplication (WGD), which is rarely observed in fungi [3, 4, 5, 6]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of P. blakesleeanus. A phototropic mutant of P. blakesleeanus with a heterozygous mutation in the photoreceptor gene madA demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes.	en
dc.description.sponsorship	The work by the US Department of Energy Joint Genome Institute, a DOE Office of Science User Facility, is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The project was supported by European funds (European Regional Development Fund, ERDF), the Spanish Ministerio de Economía y Competitividad (BIO2005-25029-E, BIO2015-67148-R), and the Regional Government (Junta de Andalucía, P06-CVI-01650) to L.M.C.; Conacyt (Mexico) (FORDECYT-2012-02-193512) to A.H.-E.; the US National Science Foundation (MCB-0920581) to A.I.; and the Czech Science Foundation (13-33039S) to M.E.	en
dc.format.extent	23 p.
dc.format.mimetype	application/pdf	en
dc.format.mimetype	application/zip	en
dc.identifier.doi	10.1016/j.cub.2016.04.038
dc.identifier.issn	0960-9822
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/38167
dc.language.iso	eng	en
dc.publisher	CellPress	en
dc.relation.ispartof	Current Biology, 2016, 26(12), 1577-1584	en
dc.relation.projectID	info:eu-repo/grantAgreement/MINECO//BIO2015-67148-R/ES/	en
dc.relation.publisherversion	https://doi.org/10.1016/j.cub.2016.04.038
dc.rights	© 2016 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0	en
dc.rights.accessRights	info:eu-repo/semantics/openAccess	en
dc.rights.accessRights	Acceso abierto / Sarbide irekia	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject	Fungi	en
dc.subject	Genome duplication	en
dc.subject	Genetics	en
dc.title	Expansion of signal transduction pathways in fungi by extensive genome duplication	en
dc.type	info:eu-repo/semantics/article	en
dc.type	Artículo / Artikulua	es
dc.type.version	info:eu-repo/semantics/acceptedVersion	en
dc.type.version	Versión aceptada / Onetsi den bertsioa	es
dspace.entity.type	Publication
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