Periostin plasma levels and changes on physical and cognitive capacities in community-dwelling older adults

Simple item page
dc.contributor.authorSánchez Sánchez, Juan Luis
dc.contributor.authorAder, Isabelle
dc.contributor.authorJeanson, Yannick
dc.contributor.authorPlanat-Benard, Valérie
dc.contributor.authorVellas, Bruno
dc.contributor.authorCasteilla, Louis
dc.contributor.authorSouto Barreto, Philipe de
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2023-05-02T09:33:41Z
dc.date.available2023-05-02T09:33:41Z
dc.date.issued2023
dc.date.updated2023-05-02T09:24:12Z
dc.description.abstractPeriostin, involved in extracellular matrix development and support, has been shown to be elevated in senescent tissues and fibrotic states, transversal signatures of aging. We aimed to explore associations between plasma periostin and physical and cognitive capacity evolution among older adults. Our hypothesis was that higher levels of plasma periostin will be associated with worse physical and mental capacities along time. Analyses included 1 096 participants (mean age = 75.3 years ± 4.4; 63.9% women) from the Multidomain Alzheimer Preventive Trial. Periostin levels (pg/mL) were measured in plasma collected at year 1. Periostin was used in continuous variable, and as a dichotomous variable highest quartile (POSTN+) versus lowest 3 quartiles (POSTN−) were used. Outcomes were measured annually over 4 years and included: gait speed (GS), short physical performance battery (SPPB) score, 5-times sit-to-stand test (5-STS), and handgrip strength (HS) as physical and cognitive composite z-score (CCS) and the Mini-Mental State Examination (MMSE) as cognitive endpoints. Plasma periostin as a continuous variable was associated with the worsening of physical and cognitive capacities over 4 years of follow-up, specifically the SPPB score, the 5-STS, and CCS in full-adjusted models. POSTN+ was associated with worse evolution in the physical (GS: [β = −0.057, 95% confidence interval (CI) = −0.101, −0.013], SPPB score [β = −0.736, 95% CI = −1.091, −0.381], 5-STS [β = 1.681, 95% CI = 0.801, 2.561]) as well as cognitive (CCS [β = −0.215, 95% CI = −0.335, −0.094]) domains compared to POSTN− group. No association was found with HS or the MMSE score. Our study showed for the first time that increased plasma periostin levels were associated with declines in both physical and cognitive capacities in older adults over a 4-year follow-up. Further research is needed to evaluate whether periostin might be used as a predictive biomarker of functional decline at an older age.en
dc.description.sponsorshipThis work was supported by grants from the Gerontopple of Toulouse, the French Ministry of Health (PHRC 2008, 2009), Pierre Fabre Research Institute (manufacturer of the omega-3 supplement), ExonHit Therapeutics SA, and Avid Radiopharmaceuticals Inc. The data-sharing activity was supported by the Association Monegasque pour la Recherche sur la maladie d'Alzheimer (AMPA) and the INSERM-University of Toulouse III UMR 1295 Unit. The present work was performed in the context of the Inspire Program, a research platform sup-ported by grants from the Region Occitanie/Pyrenees-Mediterranee (Reference number: 1901175) and the European Regional Development Fund (ERDF; Project number: MP0022856). This study received funds from Alzheimer Prevention in Occitania and Catalonia (APOC Chair of Excellence-Inspire Program)en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/msworden
dc.identifier.citationSánchez-Sánchez, J. L., Ader, I., Jeanson, Y., Planat-Benard, V., Vellas, B., Casteilla, L., & De Souto-Barreto, P. (2023). Periostin plasma levels and changes on physical and cognitive capacities in community-dwelling older adults. The Journals of Gerontology: Series A, 78(3), 424-432. https://doi.org/10.1093/gerona/glac226en
dc.identifier.doi10.1093/gerona/glac226
dc.identifier.issn1079-5006
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/45207
dc.language.isoengen
dc.publisherOxford University Pressen
dc.relation.ispartofJournal of Gerontology: Biological Sciences & Medical Sciences, 78(3), 424-432en
dc.relation.publisherversionhttps://doi.org/10.1093/gerona/glac226
dc.rights© The Author(s) 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAging biomarkeren
dc.subjectExtracellular matrixen
dc.subjectHealthy agingen
dc.titlePeriostin plasma levels and changes on physical and cognitive capacities in community-dwelling older adultsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationed9d4f53-b734-4d6e-b1b9-188a148f9a13
relation.isAuthorOfPublication.latestForDiscoveryed9d4f53-b734-4d6e-b1b9-188a148f9a13

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Sanchez_PeriostinPlasma.pdf
Size:
204.3 KB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
Sanchez_Periostin Plasma_MatCompl.docx
Size:
34.76 KB
Format:
Microsoft Word XML
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.78 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista DCS - OZS Aldizkari artikuluak
Artículos de revista - Aldizkari artikuluak