Genetic polymorphisms of CYP2C19 in Ecuadorian population: an interethnic approach

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dc.contributor.authorAlonso Llorente, Alba
dc.contributor.authorSalgado Garrido, Josefa
dc.contributor.authorTeijido Hermida, Óscar
dc.contributor.authorGonzález Andrade, Fabricio
dc.contributor.authorValiente Martín, Alberto
dc.contributor.authorFanlo Villacampa, Ana
dc.contributor.authorVicente Romero, Jorge
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2024-06-28T10:53:16Z
dc.date.available2024-06-28T10:53:16Z
dc.date.issued2024
dc.date.updated2024-06-28T10:42:05Z
dc.description.abstractIntroduction: CYP2C19 is a highly polymorphic gene responsible for metabolizing commonly used drugs. CYP2C192,3 (loss of activity alleles) and 17 (increased activity allele) are the principal alleles included in clinical guidelines, however their prevalence varies among different ethnicities. Ecuadorian population is formed by Mestizos, Afrodescendants and Native Americans and frequency of CYP2C19 alleles could be different among them. The objective of this study was to establish the frequency of these variants in the different populations of Ecuador and to compare them with other populations. Materials and methods: DNA from 105 Afrodescendants, 75 Native Americans of the Kichwa ethnicity, and 33 Mestizos Ecuadorians was analyzed by nested-PCR to identify CYP2C1917 carriers. CYP2C192 allele was analyzed in DNA from 78 Afrodescendants, 29 Native Americans of the Kichwa, and 16 Mestizos by TaqMan Allelic Discrimination Assay. CYP2C193 was analyzed in 33 Afrodescendants by nested-PCR. Results: The global frequencies of the alternate alleles were 14.22% (CYP2C192) and 2.10% (CYP2C1917). No differences (p > 0.05) were observed among the subgroups. No CYP2C193 carrier was identified. CYP2C192 frequencies in Ecuador were similar to the ones reported in Europe, Africa and Middle East countries and to some American populations. Low CYP2C1917 frequencies, like the ones in our population, were also observed in East and South Asia and in Native American groups. Discussion: Absence of differences in the ethnic groups in Ecuador for CYP2C192 and 17 could be due to either a bias in sample selection (ethnic group was assed by self-identification) or to a high interethnic admixture in the Ecuadorian population that would had diluted genetic differences. In addition, CYP2C192, *3, and *17 alleles frequencies in our study suggest that Ecuadorians ancestry is mostly of Native American origin.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAlonso Llorente, A., Salgado Garrido, J., Teijido Hermida, Ó., González Andrade, F., Valiente Martín, A., Fanlo Villacampa, A. J., Vicente Romero, J. (2024) Genetic polymorphisms of CYP2C19 in Ecuadorian population: an interethnic approach. Heliyon, 10(7), 28566-28578. https://doi.org/10.1016/j.heliyon.2024.e28566.
dc.identifier.doi10.1016/j.heliyon.2024.e28566
dc.identifier.issn2405-8440
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/50225
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofHeliyon 10(7), 28566-28578. https://doi.org/10.1016/j.heliyon.2024.e28566
dc.relation.publisherversionhttps://doi.org/10.1016/j.heliyon.2024.e28566
dc.rights© 2024 The Authors. This is an open access article under the CC BY-NC-ND license.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCYP2C19en
dc.subjectPharmacogeneticsen
dc.subjectEcuadoren
dc.subjectKichwaen
dc.subjectAfrodescendantsen
dc.subjectMestizosen
dc.titleGenetic polymorphisms of CYP2C19 in Ecuadorian population: an interethnic approachen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication78fc3a88-8473-4a7d-b1e8-21bdaf809530
relation.isAuthorOfPublication2af87636-fad2-48e3-b5f6-f4a704d93613
relation.isAuthorOfPublication.latestForDiscovery78fc3a88-8473-4a7d-b1e8-21bdaf809530

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