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Soluble ST2 as a new oxidative stress and inflammation marker in metabolic syndrome

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dc.contributor.authorRoy, Ignacio
dc.contributor.authorJover, Eva
dc.contributor.authorMatilla Cuenca, Lara
dc.contributor.authorÁlvarez, Virginia
dc.contributor.authorFernández Celis, Amaya
dc.contributor.authorBeunza, Maite
dc.contributor.authorEscribano, Elena
dc.contributor.authorGaínza Calleja, Alicia
dc.contributor.authorSádaba Sagredo, Rafael
dc.contributor.authorLópez Andrés, Natalia
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2023-08-22T11:36:18Z
dc.date.available2023-08-22T11:36:18Z
dc.date.issued2023
dc.date.updated2023-08-22T11:16:05Z
dc.description.abstractBackground: Metabolic syndrome (MS) is a complex and prevalent disorder. Oxidative stress and inflammation might contribute to the progression of MS. Soluble ST2 (sST2) is an attractive and druggable molecule that sits at the interface between inflammation, oxidative stress and fibrosis. This study aims to analyze the relationship among sST2, oxidative stress, inflammation and echocardiographic parameters in MS patients. Methods: Fifty-eight patients with MS were recruited and underwent physical, laboratory and transthoracic echocardiography examinations. Commercial ELISA and appropriate colorimetric assays were used to quantify serum levels of oxidative stress and inflammation markers and sST2. Results: Circulating sST2 was increased in MS patients and was significantly correlated with the oxidative stress markers nitrotyrosine and 8-hydroxy-2¿-deoxyguanosine as well as with peroxide levels. The inflammatory parameters interleukin-6, intercellular adhesion molecule-1 and myeloperoxidase were positively correlated with sST2. Noteworthy, sST2 was positively correlated with left ventricular mass, filling pressures and pulmonary arterial pressures. Conclusion: Circulating levels of sST2 are associated with oxidative stress and inflammation burden and may underlie the pathological remodeling and dysfunction of the heart in MS patients. Our results suggest that sST2 elevation precedes diastolic dysfunction, emerging as an attractive biotarget in MS.en
dc.description.sponsorshipThis research was funded by Miguel Servet Fellowship II contract [CP13/00221, 2018] (Natalia López-Andrés) from the “Instituto de Salud Carlos III-FEDER”; Fondo de Investigaciones Sanitarias [PI18/01875, 2018]; a PFIS PhD studentship [FI19/00302, 2020] (Lara Matilla); Postdoctoral Fellowship Sara Borrell [CD19/00251, 2020] (Eva Jover).en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRoy, I., Jover, E., Matilla, L., Alvarez, V., Fernández-Celis, A., Beunza, M., Escribano, E., Gainza, A., Sádaba, R., & López-Andrés, N. (2023). Soluble ST2 as a New Oxidative Stress and Inflammation Marker in Metabolic Syndrome. International Journal of Environmental Research and Public Health, 20(3), 2579. https://doi.org/10.3390/ijerph20032579en
dc.identifier.doi10.3390/ijerph20032579
dc.identifier.issn1661-7827
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/45988
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofInternational Journal of Environmental Research and Public Health, 2023, 20, 2579en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//CP13%2F00221/ES/CP13%2F00221/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F01875/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII//FI19%2F00302en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII//CD19%2F00251en
dc.relation.publisherversionhttps://doi.org/10.3390/ijerph20032579
dc.rights© 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectInflammationen
dc.subjectMetabolic syndromeen
dc.subjectOxidative stressen
dc.subjectSoluble ST2en
dc.titleSoluble ST2 as a new oxidative stress and inflammation marker in metabolic syndromeen
dc.typeArtículo / Artikuluaes
dc.typeinfo:eu-repo/semantics/articleen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
relation.isAuthorOfPublication803d8f90-85aa-4e9f-bfa0-30454dc4e7dd
relation.isAuthorOfPublication23d03177-1c69-4293-bfd4-1de28bf3c05b
relation.isAuthorOfPublication.latestForDiscovery803d8f90-85aa-4e9f-bfa0-30454dc4e7dd

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