Publication: Soluble ST2 as a new oxidative stress and inflammation marker in metabolic syndrome
dc.contributor.author | Roy, Ignacio | |
dc.contributor.author | Jover, Eva | |
dc.contributor.author | Matilla Cuenca, Lara | |
dc.contributor.author | Álvarez, Virginia | |
dc.contributor.author | Fernández Celis, Amaya | |
dc.contributor.author | Beunza, Maite | |
dc.contributor.author | Escribano, Elena | |
dc.contributor.author | Gaínza Calleja, Alicia | |
dc.contributor.author | Sádaba Sagredo, Rafael | |
dc.contributor.author | López Andrés, Natalia | |
dc.contributor.department | Ciencias de la Salud | es_ES |
dc.contributor.department | Osasun Zientziak | eu |
dc.date.accessioned | 2023-08-22T11:36:18Z | |
dc.date.available | 2023-08-22T11:36:18Z | |
dc.date.issued | 2023 | |
dc.date.updated | 2023-08-22T11:16:05Z | |
dc.description.abstract | Background: Metabolic syndrome (MS) is a complex and prevalent disorder. Oxidative stress and inflammation might contribute to the progression of MS. Soluble ST2 (sST2) is an attractive and druggable molecule that sits at the interface between inflammation, oxidative stress and fibrosis. This study aims to analyze the relationship among sST2, oxidative stress, inflammation and echocardiographic parameters in MS patients. Methods: Fifty-eight patients with MS were recruited and underwent physical, laboratory and transthoracic echocardiography examinations. Commercial ELISA and appropriate colorimetric assays were used to quantify serum levels of oxidative stress and inflammation markers and sST2. Results: Circulating sST2 was increased in MS patients and was significantly correlated with the oxidative stress markers nitrotyrosine and 8-hydroxy-2¿-deoxyguanosine as well as with peroxide levels. The inflammatory parameters interleukin-6, intercellular adhesion molecule-1 and myeloperoxidase were positively correlated with sST2. Noteworthy, sST2 was positively correlated with left ventricular mass, filling pressures and pulmonary arterial pressures. Conclusion: Circulating levels of sST2 are associated with oxidative stress and inflammation burden and may underlie the pathological remodeling and dysfunction of the heart in MS patients. Our results suggest that sST2 elevation precedes diastolic dysfunction, emerging as an attractive biotarget in MS. | en |
dc.description.sponsorship | This research was funded by Miguel Servet Fellowship II contract [CP13/00221, 2018] (Natalia López-Andrés) from the “Instituto de Salud Carlos III-FEDER”; Fondo de Investigaciones Sanitarias [PI18/01875, 2018]; a PFIS PhD studentship [FI19/00302, 2020] (Lara Matilla); Postdoctoral Fellowship Sara Borrell [CD19/00251, 2020] (Eva Jover). | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Roy, I., Jover, E., Matilla, L., Alvarez, V., Fernández-Celis, A., Beunza, M., Escribano, E., Gainza, A., Sádaba, R., & López-Andrés, N. (2023). Soluble ST2 as a New Oxidative Stress and Inflammation Marker in Metabolic Syndrome. International Journal of Environmental Research and Public Health, 20(3), 2579. https://doi.org/10.3390/ijerph20032579 | en |
dc.identifier.doi | 10.3390/ijerph20032579 | |
dc.identifier.issn | 1661-7827 | |
dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/45988 | |
dc.language.iso | eng | en |
dc.publisher | MDPI | en |
dc.relation.ispartof | International Journal of Environmental Research and Public Health, 2023, 20, 2579 | en |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//CP13%2F00221/ES/CP13%2F00221/ | en |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F01875/ES/ | en |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//FI19%2F00302 | en |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//CD19%2F00251 | en |
dc.relation.publisherversion | https://doi.org/10.3390/ijerph20032579 | |
dc.rights | © 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Inflammation | en |
dc.subject | Metabolic syndrome | en |
dc.subject | Oxidative stress | en |
dc.subject | Soluble ST2 | en |
dc.title | Soluble ST2 as a new oxidative stress and inflammation marker in metabolic syndrome | en |
dc.type | Artículo / Artikulua | es |
dc.type | info:eu-repo/semantics/article | en |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dspace.entity.type | Publication | |
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relation.isAuthorOfPublication.latestForDiscovery | 803d8f90-85aa-4e9f-bfa0-30454dc4e7dd |