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Valorization of onion waste by obtaining extracts rich in phenolic compounds and feasibility of its therapeutic use on colon cancer

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dc.contributor.authorPaesa, Mónica
dc.contributor.authorPires Nogueira, Danielle
dc.contributor.authorVelderrain-Rodríguez, Gustavo
dc.contributor.authorEsparza Catalán, Irene
dc.contributor.authorJiménez Moreno, Nerea
dc.contributor.authorMendoza, Gracia
dc.contributor.authorOsada, Jesús
dc.contributor.authorMartín-Belloso, Olga
dc.contributor.authorRodríguez Yoldi, María Jesús
dc.contributor.authorAncín Azpilicueta, Carmen
dc.contributor.departmentInstitute for Advanced Materials and Mathematics - INAMAT2en
dc.date.accessioned2022-06-27T06:42:55Z
dc.date.available2022-06-27T06:42:55Z
dc.date.issued2022
dc.date.updated2022-06-27T06:31:05Z
dc.description.abstractIn this study, the total phenolic content, the antioxidant and antiproliferative activities of onion waste extracts were characterized. Some phenolic compounds present in the extracts were also identified and quantified by HPLC-DAD. Additionally, an in-silico analysis was performed to identify the phenolic compounds with the highest intestinal absorption and Caco-2 permeability. The onion extract possessed a high amount of phenolic compounds (177 ± 9 mg/g extract) and had an effective antioxidant capacity measured by ABTS, FRAP and DPPH assays. Regarding the antiproliferative activity, the onion extracts produced cell cycle arrest in the S phase with p53 activation, intrinsic apoptosis (mitochondrial membrane potential modification) and caspase 3 activation. Likewise, onion waste increased intracellular ROS with possible NF-kB activation causing a proteasome down regulation. In addition, the extracts protected the intestine against oxidative stress induced by H2O2. According to the in-silico analysis, these results could be related to the higher Caco-2 permeability to protocatechuic acid. Therefore, this study provides new insights regarding the potential use of these types of extract as functional ingredients with antioxidant and antiproliferative properties and as medicinal agents in diseases related to oxidative stress, such as cancer. In addition, its valorization would contribute to the circular economy.en
dc.description.sponsorshipThis work was supported by the Grants: CIBEROBN, CB06/03/1012, 2008, Ministerio de Ciencia e Innovación-Fondo Europeo de Desarrollo Regional (PID2019-104915RB-I00), Fondo Social Europeo-Gobierno de Aragón (B16_20R) and SUDOE (Redvalue, SOE1/PI/E0123). This research was also funded by EUROPEAN UNIONS H2020 research and innovation program under Marie Sklodowska-Curie grant agreement number 801586. G.M. gratefully acknowledges the support from the Miguel Servet Program (MS19/00092; Instituto de Salud Carlos III). M.P. acknowledges the support from the Gobierno de Aragón fellowship (CUS/581/2020).en
dc.format.extent18 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPaesa, M.; Nogueira, D. P.; Velderrain-Rodríguez, G.; Esparza, I.; Jiménez-Moreno, N.; Mendoza, G.; Osada, J.; Martin-Belloso, O.; Rodríguez-Yoldi, M. J.; Ancín-Azpilicueta, C.. (2022). Valorization of onion waste by obtaining extracts rich in phenolic compounds and feasibility of its therapeutic use on colon cancer. Antioxidants. 11,4 .es_ES
dc.identifier.doi10.3390/antiox11040733
dc.identifier.issn2076-3921
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/43208
dc.language.isoengen
dc.publisherMDPIes_ES
dc.relation.ispartofAntioxidants, 2022, 11 (4), pp. 733en
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104915RB-I00/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/801586en
dc.relation.publisherversionhttps://doi.org/10.3390/antiox11040733
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.subjectAllium cepa L. by-productsen
dc.subjectCaco-2 cellsen
dc.subjectCircular economyen
dc.subjectIntestineen
dc.subjectProtocatechuic aciden
dc.subjectROSen
dc.subjectVegetable extractsen
dc.titleValorization of onion waste by obtaining extracts rich in phenolic compounds and feasibility of its therapeutic use on colon canceren
dc.typeArtículo / Artikuluaes
dc.typeinfo:eu-repo/semantics/articleen
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
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