Association between CNTF polymorphisms and adiposity markers in European adolescents

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dc.contributor.authorPascual Gamarra, José Miguel
dc.contributor.authorSalazar-Tortosa, Diego
dc.contributor.authorLabayen Goñi, Idoia
dc.contributor.authorRupérez, Azahara I.
dc.contributor.authorCensi, Laura
dc.contributor.authorBéghin, Laurent
dc.contributor.authorMichels, Nathalie
dc.contributor.authorGonzález Gross, Marcela
dc.contributor.authorManios, Yannis
dc.contributor.authorLambrinou, Christina-Paulina
dc.contributor.authorMoreno, Luis A.
dc.contributor.authorMeirhaeghe, Aline
dc.contributor.authorCastillo, Manuel J.
dc.contributor.authorRuiz, Jonatan R.
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2020-05-26T13:13:04Z
dc.date.available2021-04-01T23:00:12Z
dc.date.issued2020
dc.description.abstractObjective: To examine the association between polymorphisms of the ciliary neurotrophic factor gene (CNTF) and total and central adiposity markers in adolescents. Study design: This cross-sectional study involved 1057 European adolescents aged 12-18 years enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study. Five polymorphisms of CNTF were genotyped, and the weight, height, waist and hip circumference, and triceps and subscapular skinfold thickness of the subjects were measured and recorded. Results: The T allele of rs2509914, the C allele of rs2515363, and the G allele of rs2515362 were significantly associated (after Bonferroni correction) with higher values for several adiposity markers under different inheritance models. The CNTF CCGGA haplotype (rs2509914, rs17489568, rs2515363 rs1800169, and rs2515362) was also significantly associated with lower body mass index, waist circumference, waist/height ratio, and waist/hip ratio values compared with the TCCGG haplotype under several inheritance models. Conclusions: Three polymorphisms—rs2509914, rs2515363, and rs2515362—and the CCGGA haplotype of CNTF were significantly associated with adiposity in European adolescents. These results suggest the potential role of CTNF in the development of obesity-related phenotypes.en
dc.description.sponsorshipThe HELENA Study is supported by contract FOOD-CT-2005-007034 from the European Community Sixth RTD Framework Programme. The study was supported by the Spanish Ministry of Education (Grants FPU16/02127 and FPU13/03410); Redes Temáticas de Investigación Cooperativa (Grant Red SAMID RD16/0022); University of Granada Plan Propio de Investigación 2016 (Excellence Actions: Unit of Excellence on Exercise and Health); Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades; and European Regional Development Fund (SOMM17/6107/UGR).en
dc.embargo.lift2021-04-01
dc.embargo.terms2021-04-01
dc.format.extent19 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1016/j.jpeds.2019.12.036
dc.identifier.issn0022-3476
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/36985
dc.language.isoengen
dc.publisherMosby/Elsevieren
dc.relation.ispartofJournal of Pediatrics, 2020, 219, 23-30.e1en
dc.relation.publisherversionhttps://doi.org/10.1016/j.jpeds.2019.12.036
dc.rights© 2019 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCNTF Polymorphismsen
dc.subjectAdiposity markersen
dc.subjectAdolescentsen
dc.titleAssociation between CNTF polymorphisms and adiposity markers in European adolescentsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/embargoedAccess
dspace.entity.typePublication
relation.isAuthorOfPublicationb36e2b1d-3088-4089-806e-fd3040e9583a
relation.isAuthorOfPublication.latestForDiscoveryb36e2b1d-3088-4089-806e-fd3040e9583a

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