A sociodemographic, anthropometric and lifestyle-based prediction score for screening children with overweight and obesity for hepatic steatosis: the HEPAKID index

Osés Recalde, Maddi; Medrano Echeverría, María; Galbete Jiménez, Arkaitz; Arenaza Etxeberría, Lide; Ruiz, Jonatan R.; Sánchez-Valverde, Felix; Ortega, Francisco B.; Labayen Goñi, Idoia

Publication:
A sociodemographic, anthropometric and lifestyle-based prediction score for screening children with overweight and obesity for hepatic steatosis: the HEPAKID index

dc.contributor.author	Osés Recalde, Maddi
dc.contributor.author	Medrano Echeverría, María
dc.contributor.author	Galbete Jiménez, Arkaitz
dc.contributor.author	Arenaza Etxeberría, Lide
dc.contributor.author	Ruiz, Jonatan R.
dc.contributor.author	Sánchez-Valverde, Felix
dc.contributor.author	Ortega, Francisco B.
dc.contributor.author	Labayen Goñi, Idoia
dc.contributor.department	Ciencias de la Salud	es_ES
dc.contributor.department	Osasun Zientziak	eu
dc.date.accessioned	2021-09-06T12:27:30Z
dc.date.available	2021-12-17T00:00:12Z
dc.date.issued	2021
dc.description.abstract	Background: Hepatic steatosis (HS) is currently the most prevalent hepatic disease in paediatric population and a major risk factor for type 2 diabetes and cardiovascular diseases. The proper identification of children with HS is therefore of great public health interest. Objective: To develop a new prediction score using anthropometric, sociodemographic and lifestyle factors to identify children with HS (the HEPAKID index). Previously published biochemical paediatric screening tools were validated in the same cohort. Methods: A total of 115 pre-adolescent children aged 8 to 12 years with overweight/obesity, recruited at hospital paediatric units were enrolled in this cross-sectional study. HS (≥5.5% hepatic fat) was assessed by magnetic resonance imaging (MRI). Anthropometric, sociodemographic and lifestyle variables were collected by validated tests/questionnaires. Results: Forty-one children had MRI-diagnosed HS (35.6%, 49% girls). These children had (P <.01) a higher waist-height ratio, a lower cardiorespiratory fitness, a younger gestational age, and consumed more sugar-sweetened beverages than their HS-free peers. Children with HS were more likely to belong to an ethnic minority (P <.01) and to spend longer viewing screens than recommended (P <.05). The addition of these variables to the multivariate logistic regression model afforded a HEPAKID index with high discriminatory capacity (area under the receiver-operating characteristic curve: 0.808, 95% CI 0.715-0.901), and score of ≥25.0 was associated with high sensitivity (82%, 95% CI 68%-96%). Biochemical biomarker-based paediatric tools for identifying HS showed only moderate discriminatory capacity and low sensitivity (5%-41%) in this cohort. Conclusions: The HEPAKID index is the first simple, non-invasive, sensitive, inexpensive and easy-to-perform screening that can identify children with overweight or obesity who have HS.	en
dc.description.sponsorship	EFIGRO project was funded by the Spanish Ministry of Health ‘Fondos de Investigación Sanitaria del Instituto de Salud Carlos III’ (PI13/01335), the Spanish Ministry of Industry and Competitiveness (DEP2016‐78377‐R), by EU Fondos Estructurales de la Unión Europea (FEDER) funds (‘Una manera de hacer Europa’), and partially funded by the University of Granada Plan Propio de Investigación 2016 Excellence actions: Unit of Excellence on Exercise and Health (UCEENS, https://uceens.ugr.es ), and the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF: ref. SOMM17/6107/UGR). M.O. is supported by a grant from the Spanish Ministry of Economy and Competitiveness, grant number BES‐2017‐080770. L.A. is supported by the Education Department of the Government of the Basque Country (PRE_2016_1_0057, PRE_2017_2_0224, PRE_2018_2_0057, PRE_2019_2_0004).	en
dc.embargo.lift	2021-12-17
dc.embargo.terms	2021-12-17
dc.format.extent	34 p.
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Oses, M, Medrano, M, Galbete, A, et al. A sociodemographic, anthropometric and lifestyle-based prediction score for screening children with overweight and obesity for hepatic steatosis: The HEPAKID index. Pediatric Obesity. 2021; 16:e12770. https://doi.org/10.1111/ijpo.12770	en
dc.identifier.doi	10.1111/ijpo.12770
dc.identifier.issn	2047-6302
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/40421
dc.language.iso	eng	en
dc.publisher	Wiley	en
dc.relation.ispartof	Pediatric Obesity 2021;16:e12770	en
dc.relation.projectID	info:eu-repo/grantAgreement/MINECO//PI13%2F01335/ES/	en
dc.relation.projectID	info:eu-repo/grantAgreement/ES/1PE/DEP2016-78377-R	en
dc.relation.projectID	info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BES-2017-080770	en
dc.relation.publisherversion	https://doi.org/10.1111/ijpo.12770
dc.rights	© 2021 World Obesity Federation	en
dc.rights.accessRights	info:eu-repo/semantics/openAccess	en
dc.rights.accessRights	Acceso abierto / Sarbide irekia	es
dc.subject	Hepatic steatosis	en
dc.subject	Lifestyle behaviors	en
dc.subject	Paediatric obesity	en
dc.subject	Primary care	en
dc.subject	Screening tool	en
dc.title	A sociodemographic, anthropometric and lifestyle-based prediction score for screening children with overweight and obesity for hepatic steatosis: the HEPAKID index	en
dc.type	info:eu-repo/semantics/article	en
dc.type	Artículo / Artikulua	es
dc.type.version	info:eu-repo/semantics/acceptedVersion	en
dc.type.version	Versión aceptada / Onetsi den bertsioa	es
dspace.entity.type	Publication
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