Lifetime suicidal thoughts, attempts, and lethality of attempts as major outcome domains of psychotic disorders: a 21-year prospective cohort study after a first-episode psychosis

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dc.contributor.authorPeralta Martín, Víctor
dc.contributor.authorMoreno-Izco, Lucía
dc.contributor.authorGarcía de Jalón, Elena
dc.contributor.authorSánchez Torres, Ana María
dc.contributor.authorPeralta, David
dc.contributor.authorJanda-Galán, Lucía
dc.contributor.authorCuesta, Manuel J.
dc.contributor.authorAnsorena, X.
dc.contributor.authorBallesteros, Alejandro
dc.contributor.authorChato, J.
dc.contributor.authorFañanás, Lourdes
dc.contributor.authorGil Berrozpe, Gustavo José
dc.contributor.authorGiné-Servén, Eloi
dc.contributor.authorLorente Omeñaca, Ruth
dc.contributor.authorPapiol, S.
dc.contributor.authorRibeiro Fernández, María
dc.contributor.authorRosado, E.
dc.contributor.authorRosero, A.
dc.contributor.authorSEGPEPs Group
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
dc.date.accessioned2025-07-29T14:50:34Z
dc.date.available2025-07-29T14:50:34Z
dc.date.issued2025-03-04
dc.date.updated2025-07-29T14:22:59Z
dc.descriptionFe de erratas en https://academica-e.unavarra.es/handle/2454/54500
dc.description.abstractBackground. Suicidal thoughts and behaviors (STBs) are a major concern in people with psychotic disorders. There is a need to examine their prevalence over long-term follow-up after first-episode psychosis (FEP) and determine their early predictors. Methods. Of 510 participnts with FEP evaluated on 26 risk factors for later outcomes, 260 were reassessed after 21 years of follow-up for lifetime ratings of most severe suicidal ideation, number of suicide attempts, and lethality of the most severe attempt. Risk factors and STB outcomes were modeled using hierarchical linear regression analysis. Results. Over the 21-year follow-up period, 62.7% of participants experienced suicidal thoughts, 40.8% attempted suicide, and 18 died of suicide (3.5% case fatality and 20.6% proportionate mortality). Suicidal ideation was independently predicted by parental socioeconomic status, familial load of major depression, neurodevelopmental delay, poor adolescence social networks, and suicidal thoughts/behavior at FEP. The number of suicide attempts was independently predicted by years of follow-up, familial load of major depression, obstetric complications, childhood adversity, and suicidal thoughts/behavior at FEP. Lethality was independently predicted by familial load of major depression, obstetric complications, neurodevelopmental delay, and poor adolescence social networks. The proportion of variance in suicidal ideation, attempts, and lethality explained by the independent predictors was 29.3%, 21.2%, and 18.1%, respectively. Conclusions. STBs are highly prevalent in psychotic disorders and leads to substantial morbidity and mortality. They were predicted by a number of early risk factors, whose clinical recognition should contribute to improved prediction and prevention in people with psychotic disorders.en
dc.description.sponsorshipThis work was funded by the Instituto de Salud Carlos III, the Spanish Ministry of Science, Innovation and Universities, the European Regional Development Fund (ERDF/FEDER) (VP, gran numbers PI16/02148; EGJ and MJC, PI19/01968), and the Regional Government of Navarra (VP, grant number 31/17; LMI, grant number 41/18). Open access funding provided by Universidad Pública de Navarra.
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dc.format.mimetypeapplication/msword
dc.identifier.citationPeralta, V., Moreno-Izco, L., García de Jalón, E., Sánchez-Torres, A. M., Peralta, D., Janda, L., Cuesta, M. J., Ansorena, X., Ballesteros, A., Chato, J., Fañanás, L., Gil-Berrozpe, G., Giné-Servé, E., Lorente, R., Papiol, S., Ribeiro, M., Rosado, E., Rosero, A. (2025) Lifetime suicidal thoughts, attempts, and lethality of attempts as major outcome domains of psychotic disorders: a 21-year prospective cohort study after a first-episode psychosis. Psychological Medicine, 55, 1-10. https://doi.org/10.1017/S0033291725000443.
dc.identifier.doi10.1017/S0033291725000443
dc.identifier.issn0033-2917
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/54495
dc.language.isoeng
dc.publisherCambridge University Press
dc.relation.ispartofPsychological Medicine 2025, 55, e69, 1-10
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI16%2F02148/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICIU//PI19%2F01968/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra///
dc.relation.publisherversionhttps://doi.org/10.1017/S0033291725000443
dc.rights© The Author(s), 2025. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectFirst-episode psychosisen
dc.subjectLong-term follow-upen
dc.subjectSuicidal behavioren
dc.subjectSuicidal thoughtsen
dc.subjectSuicideen
dc.titleLifetime suicidal thoughts, attempts, and lethality of attempts as major outcome domains of psychotic disorders: a 21-year prospective cohort study after a first-episode psychosisen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication6cfdb372-fb89-4760-b1b8-404b0f0ae941
relation.isAuthorOfPublication377cf360-8d08-46f8-b10d-0785571f24c4
relation.isAuthorOfPublicationc60095c1-5436-4633-9b1c-f7d8a73c0e32
relation.isAuthorOfPublication.latestForDiscovery6cfdb372-fb89-4760-b1b8-404b0f0ae941

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