Unveiling a new selenocyanate as a multitarget candidate with anticancer, antileishmanial and antibacterial potential
| dc.contributor.author | Ramos Inza, Sandra | |
| dc.contributor.author | Henriquez-Figuereo, Andreina | |
| dc.contributor.author | Moreno, Esther | |
| dc.contributor.author | Berzosa, Melibea | |
| dc.contributor.author | Encío Martínez, Ignacio | |
| dc.contributor.author | Plano, Daniel | |
| dc.contributor.author | Sanmartín, Carmen | |
| dc.contributor.department | Ciencias de la Salud | es_ES |
| dc.contributor.department | Osasun Zientziak | eu |
| dc.date.accessioned | 2023-04-19T16:34:14Z | |
| dc.date.available | 2023-04-19T16:34:14Z | |
| dc.date.issued | 2022 | |
| dc.date.updated | 2023-04-19T16:25:30Z | |
| dc.description.abstract | Currently, cancer, leishmaniasis and bacterial infections represent a serious public health burden worldwide. Six cinnamyl and benzodioxyl derivatives incorporating selenium (Se) as selenocyanate, diselenide, or selenide were designed and synthesized through a nucleophilic substitution and/or a reduction using hydrides. Ferrocene was also incorporated by a Friedel–Crafts acylation. All the compounds were screened in vitro for their antiproliferative, antileishmanial, and antibacterial properties. Their capacity to scavenge free radicals was also assessed as a first approach to test their antioxidant activity. Benzodioxyl derivatives 2a–b showed cytotoxicity against colon (HT-29) and lung (H1299) cancer cell lines, with IC50 values below 12 µM, and were also fairly selective when tested in nonmalignant cells. Selenocyanate compounds 1–2a displayed potent antileishmanial activity in L. major and L. infantum, with IC50 values below 5 µM. They also exhibited antibacterial activity in six bacterial strains, notably in S. epidermidis with MIC and MBC values of 12.5 µg/mL. Ferrocene-containing selenide 2c was also identified as a potent antileishmanial agent with radical scavenging activity. Remarkably, derivative 2a with a selenocyanate moiety was found to act as a multitarget compound with antiproliferative, leishmanicidal, and antibacterial activities. Thus, the current work showed that 2a could be an appealing scaffold to design potential therapeutic drugs for multiple pathologies. | en |
| dc.description.sponsorship | This research was financially supported by the Plan de Investigación de la Universidad de Navarra, PIUNA (2018-19) and partially by the Institute of Tropical Health of University of Navarra (ISTUN), Caixa Foundation, Roviralta and Ubesol, Spain. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Ramos-Inza, S., Henriquez-Figuereo, A., Moreno, E., Berzosa, M., Encío, I., Plano, D., & Sanmartín, C. (2022). Unveiling a new selenocyanate as a multitarget candidate with anticancer, antileishmanial and antibacterial potential. Molecules, 27(21), 7477. https://doi.org/10.3390/molecules27217477 | en |
| dc.identifier.doi | 10.3390/molecules27217477 | |
| dc.identifier.issn | 1420-3049 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/45139 | |
| dc.language.iso | eng | en |
| dc.publisher | MDPI | en |
| dc.relation.ispartof | Molecules 2022, 27(21), 7477 | en |
| dc.relation.publisherversion | https://doi.org/10.3390/molecules27217477 | |
| dc.rights | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Antibacterial activity | en |
| dc.subject | Antileishmanial activity | en |
| dc.subject | Antioxidant | en |
| dc.subject | Cytotoxicity | en |
| dc.subject | Selenium | en |
| dc.title | Unveiling a new selenocyanate as a multitarget candidate with anticancer, antileishmanial and antibacterial potential | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | 599ca381-1fd2-4a23-93ab-4373837eb6e0 | |
| relation.isAuthorOfPublication.latestForDiscovery | 599ca381-1fd2-4a23-93ab-4373837eb6e0 |